Serum BDNF as a potential biomarker of Alzheimer's disease: verification through assessment of serum, cerebrospinal fluid, and medial temporal lobe atrophy

Y Mori, M Tsuji, T Oguchi, K Kasuga, A Kimura… - Frontiers in …, 2021 - frontiersin.org
There is an urgent need to establish blood biomarkers for Alzheimer's disease (AD).
Although it has been speculated that brain-derived neurotrophic factor (BDNF) is associated …

Stage-dependent BDNF serum concentrations in Alzheimer's disease

C Laske, E Stransky, T Leyhe, GW Eschweiler… - Journal of neural …, 2006 - Springer
Alzheimer's disease (AD) is characterized by cognitive decline and loss of neurons in
specific brain regions. Recent findings have suggested an involvement of brain-derived …

Evaluation of the diagnostic value of peripheral BDNF levels for Alzheimer's disease and mild cognitive impairment: results of a meta-analysis

B Xie, H Zhou, W Liu, W Yu, Z Liu, L Jiang… - International Journal …, 2020 - Taylor & Francis
Deregulation of brain-derived neurotrophic factor (BDNF) is a possible contributor to the
pathology and symptoms of Alzheimer's disease (AD). Most studies support an association …

Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients

C Laske, K Stellos, N Hoffmann… - International Journal …, 2011 - academic.oup.com
The neurotrophin brain-derived neurotrophic factor (BDNF) plays a critical role in neuronal
survival, synaptic plasticity, and memory. Several recent studies have demonstrated altered …

Lower cerebrospinal fluid concentration of brain-derived neurotrophic factor predicts progression from mild cognitive impairment to Alzheimer's disease

OV Forlenza, BS Diniz, AL Teixeira… - Neuromolecular …, 2015 - Springer
There is little information on the dynamics of BDNF in the CSF in the continuum between
healthy aging, MCI and AD. We included 128 older adults (77 with amnestic MCI, 26 with AD …

Brain-derived neurotrophic factor levels in Alzheimer's disease

SE O'Bryant, V Hobson, JR Hall… - Journal of …, 2009 - content.iospress.com
The current search for biomarkers that are diagnostic and/or prognostic of Alzheimer's
disease (AD) is of vital importance given the rapidly aging population. It was recently …

Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects

G Li, ER Peskind, SP Millard, P Chi, I Sokal, CE Yu… - PloS one, 2009 - journals.plos.org
Background Brain-derived neurotrophic factor (BDNF) is an activity-dependent secreted
protein that is critical to organization of neuronal networks and synaptic plasticity, especially …

Peripheral blood brain-derived neurotrophic factor as a biomarker of Alzheimer's disease: are there methodological biases?

M Balietti, C Giuli, F Conti - Molecular neurobiology, 2018 - Springer
Mounting evidence that alterations in brain-derived neurotrophic factor (BDNF) levels and
signaling may be involved in the etiopathogenesis of Alzheimer's disease (AD) has …

Decreased serum brain-derived neurotrophic factor (BDNF) levels in patients with Alzheimer's disease (AD): a systematic review and meta-analysis

TKS Ng, CSH Ho, WWS Tam, EH Kua… - International journal of …, 2019 - mdpi.com
Findings from previous studies reporting the levels of serum brain-derived neurotrophic
factor (BDNF) in patients with Alzheimer's disease (AD) and individuals with mild cognitive …

Peripheral brain-derived neurotrophic factor levels in Alzheimer's disease and mild cognitive impairment: a comprehensive systematic review and meta-analysis

BY Kim, SH Lee, PL Graham, F Angelucci, A Lucia… - Molecular …, 2017 - Springer
Alzheimer's disease (AD) is becoming a growing global problem, and there is an urgent
need to identify reliable blood biomarkers of the risk and progression of this condition. A …