ABSTRACT A characteristic of normal aging and age-related diseases is the remodeling of
the cellular organization of a tissue through polyploid cell growth. Polyploidy arises from an …

Polyploidy frequently arises in response to injury, aging, and disease. Despite its
prevalence, major gaps exist in our understanding of how polyploid cells alter tissue …

ABSTRACT A key step in tissue repair is to replace lost or damaged cells. This occurs via
two strategies: restoring cell number through proliferation or increasing cell size through …

Correct patterning of cells within an epithelium is key to establishing their normal function.
However, the precise mechanisms by which individual cells arrive at their final …

Background Reestablishing epithelial integrity and biosynthetic capacity is critically
important following tissue damage. The adult Drosophila abdominal epithelium provides an …

Tissue repair usually requires either polyploid cell growth or cell division, but the molecular
mechanism promoting polyploidy and limiting cell division remains poorly understood. Here …

In multicellular organisms, tissue integrity and organ size are maintained through removal of
aberrant or damaged cells and compensatory proliferation. Little is known, however, about …

Usually, cells balance their growth with their division. Coordinating growth inputs with cell
division ensures the proper timing of division when sufficient cell material is available and …

Coordination of growth between and within organs contributes to the generation of well-
proportioned organs and functionally integrated adults. The mechanisms that help to …

Polyploidy (the more than doubling of a cell's genome) frequently arises during
organogenesis, tissue repair, and age-associated diseases. Despite its prevalence, major …