Deconstructing virus condensation

N Lopez, G Camporeale, M Salgueiro… - PLoS …, 2021 - journals.plos.org
Viruses have evolved precise mechanisms for using the cellular physiological pathways for
their perpetuation. These virus-driven biochemical events must be separated in space and …

Liquid-liquid phase separation in viral function

X Zhang, R Zheng, Z Li, J Ma - Journal of Molecular Biology, 2023 - Elsevier
An emerging set of results suggests that liquid-liquid phase separation (LLPS) is the basis
for the formation of membrane-less compartments in cells. Evidence is now mounting that …

Liquid biomolecular condensates and viral lifecycles: review and perspectives

TA Etibor, Y Yamauchi, MJ Amorim - Viruses, 2021 - mdpi.com
Viruses are highly dependent on the host they infect. Their dependence triggers processes
of virus–host co-adaptation, enabling viruses to explore host resources whilst escaping …

New perspectives on the biogenesis of viral inclusion bodies in negative-sense RNA virus infections

O Dolnik, GK Gerresheim, N Biedenkopf - Cells, 2021 - mdpi.com
Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion
bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient …

Properties of rabies virus phosphoprotein and nucleoprotein biocondensates formed in vitro and in cellulo

Q Nevers, N Scrima, D Glon, R Le Bars… - PLoS …, 2022 - journals.plos.org
Rabies virus (RABV) transcription and replication take place within viral factories having
liquid properties, called Negri bodies (NBs), that are formed by liquid-liquid phase …

Negri bodies and other virus membrane-less replication compartments

Q Nevers, AA Albertini, C Lagaudrière-Gesbert… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Viruses reshape the organization of the cell interior to achieve different steps of their cellular
cycle. Particularly, viral replication and assembly often take place in viral factories where …

Phase transitions drive the formation of vesicular stomatitis virus replication compartments

BS Heinrich, Z Maliga, DA Stein, AA Hyman… - MBio, 2018 - Am Soc Microbiol
ABSTRACT RNA viruses that replicate in the cell cytoplasm typically concentrate their
replication machinery within specialized compartments. This concentration favors enzymatic …

Formation and function of liquid-like viral factories in negative-sense single-stranded RNA virus infections

JM Su, MZ Wilson, CE Samuel, D Ma - Viruses, 2021 - mdpi.com
Liquid–liquid phase separation (LLPS) represents a major physiochemical principle to
organize intracellular membrane-less structures. Studies with non-segmented negative …

Liquid phase partitioning in virus replication: observations and opportunities

C Wu, AS Holehouse, DW Leung… - Annual Review of …, 2022 - annualreviews.org
Viruses frequently carry out replication in specialized compartments within cells. The effect
of these structures on virus replication is poorly understood. Recent research supports …

Zinc and copper ions differentially regulate prion-like phase separation dynamics of pan-virus nucleocapsid biomolecular condensates

A Monette, AJ Mouland - Viruses, 2020 - mdpi.com
Liquid-liquid phase separation (LLPS) is a rapidly growing research focus due to numerous
demonstrations that many cellular proteins phase-separate to form biomolecular …