Flutamide reduced prostate cancer development and prostate stem cell antigen mRNA expression in high grade prostatic intraepithelial neoplasia

Z Zhigang, S Wenlu - International journal of cancer, 2008 - Wiley Online Library
High‐grade prostatic intraepithelial neoplasia (HGPIN) appears to represent an ideal target
for chemoprevention of prostate cancer (PCa). HGPIN responds to androgen ablation and …

Flutamide in men with prostatic intraepithelial neoplasia: a randomized, placebo-controlled chemoprevention trial

SR Alberts, PJ Novotny, JA Sloan… - American journal of …, 2006 - journals.lww.com
High-grade prostatic intraepithelial neoplasia (HGPIN) has been identified as a
premalignant change in the prostate that indicates increased risk of the subsequent …

Chemoprevention for prostatic carcinoma: the role of flutamide in patients with prostatic intraepithelial neoplasia

SR Alberts, ML Blute - Urology, 2001 - Elsevier
High-grade prostatic intraepithelial neoplasia (HGPIN) is believed to be a precursor for
prostatic adenocarcinoma. The prevalence of prostatic intraepithelial neoplasia (PIN) …

Prostatic intraepithelial neoplasia: an update

L Cheng, RF Paterson, SDW Beck, J Parks - Clinical Prostate Cancer, 2004 - Elsevier
High-grade prostatic intraepithelial neoplasia (HGPIN) is commonly encountered on
prostate needle biopsies and, based on epidemiologic, molecular, and animal models, has …

Dutasteride for the prevention of prostate cancer in men with high-grade prostatic intraepithelial neoplasia: results of a phase III randomized open-label 3-year trial

D Milonas, S Auskalnis, G Skulcius… - World journal of …, 2017 - Springer
Purpose High-grade prostatic intraepithelial neoplasia (HGPIN) is a potential precursor of
prostate cancer (PCa), and patients with HGPIN are at high risk for PCa development …

[HTML][HTML] Drug therapies for eradicating high-grade prostatic intraepithelial neoplasia in the prevention of prostate cancer

SS Taneja - Reviews in urology, 2005 - ncbi.nlm.nih.gov
High-grade prostatic intraepithelial neoplasia (HGPIN) is a precursor to invasive prostate
cancer observed as an isolated entity in a growing subset of men undergoing prostate …

[HTML][HTML] Prostatic intraepithelial neoplasia: an overview

MK Brawer - Reviews in urology, 2005 - ncbi.nlm.nih.gov
Prostatic intraepithelial neoplasia (PIN) is the most established precursor of prostatic
carcinoma. The presence of prominent nucleoli within an existing duct structure is an easy …

High-grade prostatic intraepithelial neoplasia as an exposure biomarker for prostate cancer chemoprevention research.

JR Marshall - IARC Scientific Publications, 2001 - europepmc.org
There is a tremendous need for exposure biomarkers, which need to function as
intermediate end-points in cancer chemoprevention studies. Likely candidates include …

[PDF][PDF] Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial

JL Capodice, P Gorroochurn… - Journal of the Society …, 2009 - researchgate.net
Subjects diagnosed with high-grade prostatic intraepithelial neoplasia (HGPIN) at biopsy
are at increased risk for developing prostate cancer (CaP). A prospective clinical trial was …

Prostate–Specific Antigen Levels and Clinical Response to Flutamide as the Second Hormone Therapy for Hormone–Refractory Prostate Carcinoma

K Fujikawa, Y Matsui, S Fukuzawa, H Takeuchi - European urology, 2000 - karger.com
Background: Some authors have recently reported that maximum androgen block (MAB), in
which the nonsteroidal anti–androgen, flutamide, is used together with conventional …