Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in …
Patients with schizophrenia have consistently shown brain volumetric abnormalities,
implicating both etiological and pathological processes. However, the genetic relationship …
implicating both etiological and pathological processes. However, the genetic relationship …
Genetic overlap between schizophrenia and volumes of hippocampus, putamen, and intracranial volume indicates shared molecular genetic mechanisms
Schizophrenia (SCZ) is associated with differences in subcortical brain volumes and
intracranial volume (ICV). However, little is known about the underlying etiology of these …
intracranial volume (ICV). However, little is known about the underlying etiology of these …
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and
function differ, on average, between people with schizophrenia and healthy individuals. As …
function differ, on average, between people with schizophrenia and healthy individuals. As …
Genetic association between schizophrenia and cortical brain surface area and thickness
Importance Schizophrenia is a complex heritable disorder associated with many genetic
variants, each with a small effect. While cortical differences between patients with …
variants, each with a small effect. While cortical differences between patients with …
Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia
Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
Genetic correlations between subcortical brain volumes and psychiatric disorders
K Ohi, T Shimada, Y Kataoka, T Yasuyama… - The British Journal of …, 2020 - cambridge.org
Psychiatric disorders as well as subcortical brain volumes are highly heritable. Large-scale
genome-wide association studies (GWASs) for these traits have been performed. We …
genome-wide association studies (GWASs) for these traits have been performed. We …
Association of a schizophrenia-risk nonsynonymous variant with putamen volume in adolescents: a voxelwise and genome-wide association study
Importance Deviation from normal adolescent brain development precedes manifestations
of many major psychiatric symptoms. Such altered developmental trajectories in adolescents …
of many major psychiatric symptoms. Such altered developmental trajectories in adolescents …
Genetic schizophrenia risk variants jointly modulate total brain and white matter volume
AFT Van Scheltinga, SC Bakker, NEM Van Haren… - Biological …, 2013 - Elsevier
BACKGROUND: Thousands of common single nucleotide polymorphisms (SNPs) are
weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs …
weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs …
Heritability of subcortical and limbic brain volume and shape in multiplex-multigenerational families with schizophrenia
Background Brain abnormalities of subcortical and limbic nuclei are common in patients with
schizophrenia, and variation in these structures is considered a putative endophenotype for …
schizophrenia, and variation in these structures is considered a putative endophenotype for …
Predicting brain structure in population‐based samples with biologically informed genetic scores for schizophrenia
S Van der Auwera, K Wittfeld… - American Journal of …, 2017 - Wiley Online Library
Schizophrenia is associated with brain structural abnormalities including gray and white
matter volume reductions. Whether these alterations are caused by genetic risk variants for …
matter volume reductions. Whether these alterations are caused by genetic risk variants for …