Brain postnatal development is characterized by critical periods of experience-dependent
remodeling of neuronal circuits. Failure to end these periods results in neurodevelopmental …

The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and
memory are still poorly explored. Astrocytes form large intercellular networks by gap junction …

Sensory experience in early life shapes the mammalian brain. An impairment in the activity-
dependent refinement of functional connections within developing visual cortex was …

Accumulating evidence suggests that global depletion of adult hippocampal neurogenesis
influences its function and that the timing of the depletion affects the deficits. However, the …

▪ Abstract Neuronal circuits are shaped by experience during critical periods of early
postnatal life. The ability to control the timing, duration, and closure of these heightened …

Sensory experience physically rewires the brain in early postnatal life through unknown
processes. Here, we identify a robust anatomical consequence of monocular deprivation …

Sensory experience in early postnatal life, during so-called critical periods, restructures
neural circuitry to enhance information processing. Why the cortex is susceptible to sensory …

Critical periods—brief intervals during which neural circuits can be modified by activity—are
necessary for proper neural circuit assembly. Extended critical periods are associated with …

The role of postnatal experience in sculpting cortical circuitry, while long appreciated, is
poorly understood at the level of cell types. We explore this in the mouse primary visual …

Since the discovery of ocular dominance plasticity, neuroscientists have understood that
changes in visual experience during a discrete developmental time, the critical period …