With numerous recent advances, the field of therapeutic nucleic acid nanotechnology is now
poised for clinical translation supported by several examples of FDA-approved nucleic acid …

606Recent clinical successes using therapeutic nucleic acids (TNAs) have accelerated the
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …

Nucleic acid therapeutics offer a new paradigm to rapidly respond to global health problems.
The versatility of nucleic acids, especially in RNA therapies, provides the ability to tune …

In recent years, the main quest of science has been the pioneering of the groundbreaking
biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids …

Conspectus The outbreak of the coronavirus disease 2019 (COVID-19) pandemic and swift
approval of two mRNA vaccines have put nucleic acid therapeutics in the spotlight of both …

Nucleic acids have been utilized to construct an expansive collection of nanoarchitectures
varying in design, physicochemical properties, cellular processing and biomedical …

Nucleic acid vaccines are a method of immunization aiming to elicit immune responses akin
to live attenuated vaccines. In this method, DNA or messenger RNA (mRNA) sequences are …

The rapid development of nanotechnology has a great influence on the fields of biology,
physiology, and medicine. Over recent years, nanoparticles have been widely presented as …

Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications
that enabled the development of effective mRNA vaccines against COVID-19. Early research …

Due to a series of systemic and intracellular obstacles in nucleic acid (NA) therapy, including
fast degradation in blood, renal clearance, poor cellular uptake, and inefficient endosomal …