Germ cell specification is the first step for developing reproductive cells. The specification
requires formative pluripotent stem cells as precursors. Previous attempts to capture …

Human fertility is dependent upon the correct establishment and differentiation of the
germline. This is because no other cell type in the body is capable of passing a genome and …

Germline specification underlies human reproduction and evolution, but it has proven
difficult to study in humans since it occurs shortly after blastocyst implantation. This process …

Generating primordial germ cells (PGCs) from human pluripotent stem cells (hPSCs)
advances studies of human reproduction and development of infertility treatments, but …

Mechanisms underlying human germ cell development are unclear, partly due to difficulties
in studying human embryos and lack of suitable experimental systems. Here, we show that …

Generating primordial germ cell-like cells (PGCLCs) from human pluripotent stem cells
(hPSCs) advances studies of human reproduction and development of infertility treatments …

Infertility is caused by a multitude of genetic and environmental factors, and many who seek
treatment are unresponsive to in vitro fertilization. Treatments such as these are costly, as …

Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for
germline and soma formation, and then undergo lineage priming. Mouse embryonic stem …

Germ cells are unique cell types that generate a totipotent zygote upon fertilization, giving
rise to the next generation in mammals and many other multicellular organisms. How germ …

In mammals, pluripotent cells transit through a continuum of distinct molecular and functional
states en route to initiating lineage specification. Capturing pluripotent stem cells (PSCs) …