[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Targeting adipose tissue in the treatment of obesity-associated diabetes

CM Kusminski, PE Bickel, PE Scherer - Nature reviews Drug discovery, 2016 - nature.com
Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Adipose tissue inflammation and cardiovascular disease: an update

MN Rana, IJ Neeland - Current diabetes reports, 2022 - Springer
Abstract Purpose of Review The obesity epidemic is on the rise, and while it is well known
that obesity is associated with an increase in cardiovascular risk factors such as type 2 …

Heterogeneity of white adipose tissue: molecular basis and clinical implications

KHM Kwok, KSL Lam, A Xu - Experimental & molecular medicine, 2016 - nature.com
Adipose tissue is a highly heterogeneous endocrine organ. The heterogeneity among
different anatomical depots stems from their intrinsic differences in cellular and physiological …

Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease

JJ Fuster, N Ouchi, N Gokce, K Walsh - Circulation research, 2016 - Am Heart Assoc
Obesity is causally linked with the development of cardiovascular disorders. Accumulating
evidence indicates that cardiovascular disease is the collateral damage of obesity-driven …

Adipose tissue macrophages as potential targets for obesity and metabolic diseases

X Li, Y Ren, K Chang, W Wu, HR Griffiths, S Lu… - Frontiers in …, 2023 - frontiersin.org
Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose
tissue dysfunction and contributing to obesity-induced inflammation and metabolic …

The role of adipose tissue in cardiovascular health and disease

EK Oikonomou, C Antoniades - Nature Reviews Cardiology, 2019 - nature.com
Accumulating knowledge on the biology and function of the adipose tissue has led to a
major shift in our understanding of its role in health and disease. The adipose tissue is now …

Diabetes mellitus and its metabolic complications: the role of adipose tissues

L Dilworth, A Facey, F Omoruyi - International journal of molecular …, 2021 - mdpi.com
Many approaches have been used in the effective management of type 2 diabetes mellitus.
A recent paradigm shift has focused on the role of adipose tissues in the development and …

Morphological and inflammatory changes in visceral adipose tissue during obesity

XS Revelo, H Luck, S Winer, DA Winer - Endocrine pathology, 2014 - Springer
Obesity is a major health burden worldwide and is a major factor in the development of
insulin resistance and metabolic complications such as type II diabetes. Chronic nutrient …

The multifaceted roles of adipose tissue—therapeutic targets for diabetes and beyond: The 2015 Banting Lecture

PE Scherer - Diabetes, 2016 - Am Diabetes Assoc
The Banting Medal for Scientific Achievement is the highest scientific award of the American
Diabetes Association (ADA). Given in memory of Sir Frederick Banting, one of the key …