Voltage-gated T-type calcium channel modulation by kinases and phosphatases: the old ones, the new ones, and the missing ones

A Sharma, G Rahman, J Gorelik, A Bhargava - Cells, 2023 - mdpi.com
Calcium (Ca2+) can regulate a wide variety of cellular fates, such as proliferation, apoptosis,
and autophagy. More importantly, changes in the intracellular Ca2+ level can modulate …

T-type calcium channels in cancer

L Antal, M Martin-Caraballo - Cancers, 2019 - mdpi.com
Although voltage-activated Ca2+ channels are a common feature in excitable cells, their
expression in cancer tissue is less understood. T-type Ca2+ channels are particularly …

T-Type calcium channels: a mixed blessing

D Melgari, A Frosio, S Calamaio, GA Marzi… - International Journal of …, 2022 - mdpi.com
The role of T-type calcium channels is well established in excitable cells, where they preside
over action potential generation, automaticity, and firing. They also contribute to intracellular …

Amazing T-type calcium channels: updating functional properties in health and disease

B Nilius, E Carbone - Pflügers Archiv-European Journal of Physiology, 2014 - Springer
T-type Ca 2+ channels have gained, 15 years after cloning, an immense interest as novel
players in very unexpected cell functions, and its many relations to diseases have been …

T-type calcium channels: the never ending story

B Nilius, K Talavera, A Verkhratsky - Cell calcium, 2006 - Elsevier
T-type, or low-voltage-activated (LVA), tiny and transient Ca2+ currents pare more and more
recognised as universal players in a plethora of cell functions and are also more and more …

[HTML][HTML] Regulation of T-type calcium channels: signalling pathways and functional implications

S Huc, A Monteil, I Bidaud, G Barbara, J Chemin… - … et Biophysica Acta (BBA …, 2009 - Elsevier
T-type calcium channels (T-channels) contribute to a wide variety of physiological functions,
especially in the cardiovascular and nervous systems. Recent studies using knock-out …

Towards the discovery of novel T-type calcium channel blockers

P Lory, J Chemin - Expert opinion on therapeutic targets, 2007 - Taylor & Francis
Despite their presence in many tissues and their potential implication in various disease
states, low-voltage activated T-type calcium channels (T-channels) have only recently …

T-type calcium channels in differentiation and proliferation

P Lory, I Bidaud, J Chemin - Cell calcium, 2006 - Elsevier
Low-voltage activated, T-type calcium channels (T-channels) are expressed in many
developing tissues and may be important in regulating important cellular phenotype …

L-type voltage-dependent calcium channels as therapeutic targets for neurodegenerative diseases

T Yagami, H Kohma… - Current medicinal …, 2012 - ingentaconnect.com
Ca2+ is a highly versatile intracellular second messenger in the central nervous system, and
regulates many complicated cellular processes, including excitation, plasticity and …

The T-type calcium channelosome

N Weiss, GW Zamponi - Pflügers Archiv-European Journal of Physiology, 2024 - Springer
T-type calcium channels perform crucial physiological roles across a wide spectrum of
tissues, spanning both neuronal and non-neuronal system. For instance, they serve as …