Unveiling the anti-senescence effects and senescence-associated secretory phenotype (SASP) inhibitory mechanisms of Scutellaria baicalensis Georgi in low …
L Gao, W Yang, H Qi, CJ Sun, X Qin, G Du - Phytomedicine, 2022 - Elsevier
Background Astrocytes senescence has been demonstrated in the aging brain and
Alzheimer's disease (AD). Moreover, lower glucose metabolism has been confirmed in the …
Alzheimer's disease (AD). Moreover, lower glucose metabolism has been confirmed in the …
Baicalein Delays H2O2-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF …
L Gao, W Zheng, X Wu, G Du, X Qin - ACS Chemical …, 2021 - ACS Publications
Baicalein is an active ingredient extracted from the dried roots of the Scutellaria baicalensis
Georgi. It has been demonstrated to improve memory impairment in multiple animal models; …
Georgi. It has been demonstrated to improve memory impairment in multiple animal models; …
[HTML][HTML] The leaves of Scutellaria baicalensis Georgi attenuate brain aging in D-galactose-induced rats via regulating glutamate metabolism and Nrf2 signaling …
M Li, L Yang, L Gao, G Du, X Qin, Y Zhou - Experimental Gerontology, 2022 - Elsevier
The present study aimed to evaluate the anti-aging effect of the leaves of Scutellaria
baicalensis Georgi (LSBG) and investigate its mechanisms. For this purpose, SD rats were …
baicalensis Georgi (LSBG) and investigate its mechanisms. For this purpose, SD rats were …
[HTML][HTML] Scutellaria baicalensis Georgi stems and leaves flavonoids promote neuroregeneration and ameliorate memory loss in rats through cAMP-PKA-CREB …
Y Yao, Q Liu, S Ding, Y Chen, T Song, Y Shang - Heliyon, 2024 - cell.com
The aim of this study was to investigate the possible molecular mechanism of Scutellaria
baicalensis Georgi stems and leaves flavonoids (SSF) in Alzheimer's disease (AD). The …
baicalensis Georgi stems and leaves flavonoids (SSF) in Alzheimer's disease (AD). The …
The anti-aging effect of Scutellaria baicalensis Georgi flowers extract by regulating the glutamine-glutamate metabolic pathway in d-galactose induced aging rats
J Song, Y Zhou, Y Pang, L Gao, G Du, X Qin - Experimental Gerontology, 2020 - Elsevier
Scutellaria baicalensis Georgi flowers is rich in flavonoids resources but not effectively
exploited. This study aimed to investigate the anti-aging effects and potential mechanism of …
exploited. This study aimed to investigate the anti-aging effects and potential mechanism of …
Effects of baicalein on cortical proinflammatory cytokines and the intestinal microbiome in senescence accelerated mouse prone 8
L Gao, J Li, Y Zhou, X Huang, X Qin… - ACS chemical …, 2018 - ACS Publications
Baicalein, a flavonoid derived from the roots of Scutellariae baicalensis Georgi, has shown
health benefits for an array of human diseases including dementia. The senescence …
health benefits for an array of human diseases including dementia. The senescence …
Gastrodiae rhizoma attenuates brain aging via promoting neuritogenesis and neurodifferentiation
WH Hsu, NK Huang, YJ Shiao, CK Lu, YM Chao… - Phytomedicine, 2021 - Elsevier
Abstract Background Gastrodiae Rhizoma (Tianma), the dried tuber of Gastrodia elata
Bl.(Orchidaceae), is listed as a top-grade herbal medicine in Shen-nong Ben-ts' ao Jing and …
Bl.(Orchidaceae), is listed as a top-grade herbal medicine in Shen-nong Ben-ts' ao Jing and …
Polygonatum kingianum saponins delay cellular senescence through SASP down-regulation and prolong the healthy lifespan of Caenorhabditis elegans by activating …
JJ Yang, SL Zhao, X Zhang, YG Ma, JG Jiang - Industrial Crops and …, 2023 - Elsevier
Polygonatum kingianum has been widely regarded as a potential resource for anti-aging. In
this study, we aimed to investigate the specific effect and action mechanism of saponins, the …
this study, we aimed to investigate the specific effect and action mechanism of saponins, the …
Mechanism and Molecular Targets of a Water-Soluble Extract of Artemisia annua on the Treatment of Alzheimer's Disease Based on Network Pharmacology and …
WS Zhou, M Silva, C Yang, S Li, YT Chen… - The American Journal …, 2023 - World Scientific
Oxidative stress is an important contributor to the pathogenesis of Alzheimer's disease (AD).
The overproduction of reactive oxygen species observed in AD patients results in the loss of …
The overproduction of reactive oxygen species observed in AD patients results in the loss of …
Flavonoids from Scutellaria baicalensis inhibit senescence-associated secretory phenotype production by interrupting IκBζ/C/EBPβ pathway: Inhibition of age-related …
H Lim, YS Kwon, D Kim, J Lee, HP Kim - Phytomedicine, 2020 - Elsevier
Background Prolonged exposure to the senescence-associated secretory phenotype
(SASP) with age leads to chronic low-grade inflammation in neighboring cells and tissues …
(SASP) with age leads to chronic low-grade inflammation in neighboring cells and tissues …