The genome-wide identification of gene functions in malaria parasites is hampered by a lack
of reverse genetic screening methods. We present a large-scale resource of barcoded …

Experimental reverse genetic approaches have proven powerful in the study of the biology
of the malaria parasite. The murine malaria model parasite Plasmodium berghei is the …

The identification of parasite genes controlling phenotypes such as drug resistance,
virulence, immunogenicity, and transmission is vital to malaria research. Classical genetic …

Abstract The Plasmodium Genetic Modification (Plasmo GEM) database (http://plasmogem.
sanger. ac. uk) provides access to a resource of modular, versatile and adaptable vectors for …

The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

In malaria parasites, the systematic experimental validation of drug and vaccine targets by
reverse genetics is constrained by the inefficiency of homologous recombination and by the …

Molecular approaches have an increasingly recognized utility in surveillance of malaria
parasite populations, not only in defining prevalence and incidence with higher sensitivity …

For many pathogens the availability of genome sequence, permitting genome-dependent
methods of research, can partially substitute for powerful forward genetic methods (genome …

Malaria remains one of the most devastating infectious diseases. Reverse genetic screens
offer a powerful approach to identify genes and molecular processes governing malaria …

Plasmodium berghei was identified as a parasite of thicket rats (Grammomys dolichurus)
and Anopheles dureni mosquitoes in African highland forests. Successful adaptation to a …