The aging process is driven by multiple mechanisms that lead to changes in energy
production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality …

Ageing is an inexorable intrinsic process that affects all cells, tissues, organs and
individuals. Due to a diminished homeostasis and increased organism frailty, ageing causes …

Abstract The National Institutes of Health (NIH) Geroscience Interest Group (GSIG)
sponsored workshop, The Role of Inflammation in Age-Related Disease, was held …

Ageing is a multifactorial physiological manifestation that occurs inexorably and gradually in
all forms of life. This process is linked to the decay of homeostasis due to the progressive …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Inflammation is considered a response set by the tissues in response to injury elicited by
trauma or infection. It is a complex network of molecular and cellular interactions that …

A typical feature of ageing is a chronic, low-grade inflammation characterized by a general
increase in the production of proinflammatory cytokines and inflammatory markers (“inflamm …

The aging process is driven by interrelated mechanisms that lead to the emergence of
characteristic phenotypes that include changes in body composition, energy production and …

The process of maintaining life for the individual is a constant struggle to preserve his/her
integrity. This can come at a price when immunity is involved, namely systemic inflammation …

Highlights•Elderly people commonly show signs of low level systemic inflammation.•Causes
include presence of senescent cells, chronic infections and obesity.•Systemic inflammation …