Sialic acids (SA) are a kind of nine-carbon backbone sugars, serving as important molecules
in cell-to-cell or cell-to-extra-cellular matrix interaction mediated by either O-linked …

Sialylation (the covalent addition of sialic acid to the terminal end of glycoproteins or
glycans), tightly regulated cell-and microenvironment-specific process and orchestrated by …

Gynecological cancers are in the top 10 of most common cancers in women. Survival and
outcome are strongly related to the stage at diagnosis. Therefore, early diagnosis is …

Tumorigenesis and metastasis are frequently associated with altered structure and
expression of oligosaccharides on cell surface glycoproteins and glycolipids. The …

Sialic acid (SA), as the ultimate epitope of polysaccharides, can act as a cap at the end of
polysaccharide chains to prevent their overextension. Sialylation is the enzymatic process of …

Simple Summary Sialylation is a post-translational modification that consists in the addition
of sialic acid to growing glycan chains on glycoproteins and glycolipids. Aberrant sialylation …

Simple Summary Sialylation is the synthetic process of sialoglycans, which are important in
tumor transformation, proliferation, metastasis, and immune evasion. The primary subjects of …

OBJECTIVE.: Aberrant glycosylation occurs in essentially all types of experimental and
human cancers, and many glycosyl epitopes constitute tumor-associated antigens (for …

The hallmarks of cancer are characterized by functional capabilities that allow cancer cells
to survive, proliferate and disseminate during the multistep tumorigenesis. Cancer being a …

Cancer is a major cause of death in both developing and developed countries. Early
detection and efficient therapy can greatly enhance survival. Aberrant glycosylation has …