Synthetic biology offers a new path for the exploitation and improvement of natural products
to address the growing crisis in antibiotic resistance. All antibiotics in clinical use are facing …

Modification of natural product backbones is a proven strategy for the development of
clinically useful antibiotics. Such modifications have traditionally been achieved through …

The glycopeptide antibiotics are the most important class of drugs used in the treatment of
resistant bacterial infections including those caused by methicillin-resistant Staphylococcus …

The accelerated appearance of drug-resistant bacteria poses an ever-growing threat to
modern medicine's capacity to fight infectious diseases. Gram-positive species such as …

Glycopeptide antibiotics are clinically important medicines to treat serious Gram-positive
bacterial infections. The emergence of glycopeptide resistance among pathogens has …

Glycopeptide antibiotics are produced by Actinobacteria through biosynthetic gene clusters
that include genes supporting their regulation, synthesis, export and resistance. The …

Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander
Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become …

Highlights•Medicinal chemistry generates improved antibiotics from core scaffolds that can
evade resistance.•Antibiotic chemical space is different than that of other drugs.•Antibiotic …

Highlights•Aminoglycosides have been and will be treasured anti-infective against
'superbugs'.•Aminoglycosides' defensive structural features are clues for antibiotic …

Natural products are the greatest source of antimicrobial agents, although their structural
complexity often renders synthetic production and diversification of key classes impractical …