Purpose: The pathogenesis of the lacrimal glands (LGs) is facilitated by inflammation
mediated by the NACHT, LRR, and NLRP3 inflammasomes in dry eye disease. This …

Purpose AQP5−/− mice spontaneously exhibit dry eye symptoms. The purpose of this study
was to assess the endoplasmic reticulum (ER) stress-mediated inflammation generated by a …

Tear film hyperosmolarity along with exposure to oxidant stress are factors that can induce
chronic ocular surface inflammation and pain. However, there is limited information on how …

In studies on dry eye (DE) disease, an association has been identified between tear film
hyperosmolarity and inflammation severity elicited through receptor-induced increases in …

Purpose To evaluate the mRNA and protein expressions of NLRP3 inflammasome and its
downstream inflammatory factors in human dry eye. Methods We recruited 54 patients with …

purpose. The objective of this study was to investigate whether leakage of aquaporin 5
(AQP5) in tear is associated with damage of lacrimal glands (LGs) in dacryoadenitis models …

Purpose: Inflammasomes are multiprotein complexes that detect danger-associated signals
and trigger an immunostimulatory form of cell death called pyroptosis. NLRP1 is an innate …

Purpose Mooren's ulcer (MU) is a peripheral corneal ulceration of presumed autoimmune
etiology. NLRP3 inflammasome has been shown to be involved in a variety of autoimmune …

Purpose To explore the role of nucleotide-binding oligomerization domain-like receptors
(NLRs) family caspase-activation and the recruitment domain containing 4 (NLRC4) …

Lacrimal gland inflammation triggers dry eye disease through impaired tear secretion by the
epithelium. As aberrant inflammasome activation occurs in autoimmune disorders including …