It is well established that early life environmental signals, including nutrition, set the stage for
long-term health and disease risk–effects that span multiple generations. This relationship …

BACKGROUND According to the Developmental Origins of Health and Disease (DOHaD)
hypothesis, environmental changes taking place during early maturational periods may alter …

There are now robust data supporting the Developmental Origins of Health and Disease
(DOHaD) paradigm. This includes human and animal data focusing on nutrition or …

ABSTRACT “Barker's hypothesis” emerged almost 25 years ago from epidemiological
studies of birth and death records that revealed a high geographic correlation between rates …

There is now considerable epidemiological and experimental evidence indicating that early-
life environmental conditions, including nutrition, affect subsequent development in later life …

The concept emerging from Professor David Barker's seminal research on the
developmental origins of later-life disease has progressed in many directions since it was …

Maternal and paternal factors influence offspring development and program its genome for
successful postnatal life. Based on the stressors during gestation, the pregnant female …

Abstract The Developmental Origins of Health and Disease (DOHaD) paradigm is one of the
most rapidly expanding areas of biomedical research. Environmental stressors that can …

BACKGROUND There is now compelling evidence that long-term health and physiological
function are modified by events that occur early in life and involve interactions between the …

Accumulating evidence suggest that the concept of programming can also be applied to
reproductive development and function, representing an ever expanding research area …