Timing is essential for many cellular processes, from cellular responses to external stimuli to
the cell cycle and circadian clocks. Many of these processes are based on gene expression …

In the noisy cellular environment, gene products are subject to inherent random fluctuations
in copy numbers over time. How cells ensure precision in the timing of key intracellular …

The small number of reactant molecules involved in gene regulation can lead to significant
fluctuations in intracellular mRNA and protein concentrations, and there have been …

Transcriptional regulation is an inherently noisy process. The origins of this stochastic
behavior can be traced to the random transitions among the discrete chemical states of …

Background The need to execute a sequence of events in an orderly and timely manner is
central to many biological processes, including cell cycle progression and cell …

Cells are the fundamental units of life, and like all life forms, they change over time. Changes
in cell state are driven by molecular processes; of these many are initiated when molecule …

The stochastic nature of gene expression can lead to significant cell-to-cell variability in the
time at which a certain protein level is attained. This is reflected in the timing of cellular …

The creation of protein from DNA is a dynamic process consisting of numerous reactions,
such as transcription, translation and protein folding. Each of these reactions is further …

Stochastic models of reaction networks are widely used to depict gene expression
dynamics. However, stochastic does not necessarily imply accurate, as subtle assumptions …

In biochemical signaling, information is often encoded in oscillatory signals. However, the
advantages of such a coding strategy over an amplitude-encoding scheme of constant …