The blood–brain barrier (BBB) undergoes functional changes with aging which may
contribute to cognitive decline. A novel, diffusion prepared arterial spin labeling-based MRI …

Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders,
including cerebral small vessel disease and Alzheimer's disease. An emerging biomarker of …

Purpose To present a novel MR pulse sequence and modeling algorithm to quantify the
water exchange rate (kw) across the blood–brain barrier (BBB) without contrast, and to …

Purpose A fundamental goal in the drive to understand and find better treatments for
dementia is the identification of the factors that render the aging brain vulnerable to …

Introduction We tested if water exchange across the blood‐brain barrier (BBB), estimated
with a noninvasive magnetic resonance imaging (MRI) technique, is associated with …

Background and Objectives There is an increasing awareness of the “Heart-Brain
Connection,” whereby cardiovascular function is connected with cognition. Diffusion-MRI …

ABSTRACT BACKGROUND AND PURPOSE Transvascular water exchange plays a key
role in the functional integrity of the blood–brain barrier (BBB). In white matter (WM), a …

Vascular risk factors (eg, obesity and hypertension) are associated with cerebral small
vessel disease, Alzheimer's disease (AD) pathology, and dementia. Reduced perfusion may …

To investigate whether blood–brain barrier (BBB) disruption is a potential mechanism of
usual age-related cognitive decline, we conducted dynamic contrast–enhanced (DCE) MRI …

Background The blood–brain barrier (BBB) plays a vital role in maintaining brain
homeostasis, but the integrity of this barrier deteriorates slowly with aging. Noninvasive …