Summary Cyclic GMP-AMP synthase (cGAS) is the major sensor for cytosolic DNA and
activates type I interferon signaling and plays an essential role in antitumor immunity …

Activation of the cGAS/STING innate immunity pathway is essential and effective for anti-
tumor immunotherapy. However, it remains largely elusive how tumor-intrinsic cGAS …

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that initiates innate immune
responses. DNA-bound cGAS produces cyclic GMP-AMP (cGAMP), which activates …

The discovery of cancer immune surveillance and immunotherapy has opened up a new era
of cancer treatment. Immunotherapies modulate a patient's immune system to specifically …

Cancer immunotherapy is arguably the most rapidly advancing realm of cancer treatment.
Glutathione peroxidase 4 (GPX4) has emerged as the vital enzyme to prevent lipid …

Recent evidence shows that cyclic GMP-AMP synthase (cGAS)/stimulator of interferon (IFN)
genes (STING) signaling is essential for antitumor immunity by inducing the production of …

Cyclic GMP-AMP (cGAMP) is an intracellular second messenger that is synthesized in
response to cytosolic double-stranded DNA and activates the innate immune STING …

Cyclic GMP-AMP synthase (cGAS) binds to microbial and self-DNA in the cytosol and
synthesizes cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes …

Objective Intrahepatic cholangiocarcinoma (ICC) exhibits very low response rate to immune
checkpoint inhibitors (ICIs) and the underlying mechanism is largely unknown. We …

DNA methylation abnormality is closely related to tumor occurrence and development.
Chemical inhibitors targeting DNA methyltransferase (DNMTis) have been used in treating …