Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent
on a sustained energy supply and adequate calcium buffering, both of which are provided …

The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac
adaptation to pressure or volume overload is associated with a complex molecular change …

Mitochondria are essential for energy supply and cell signalling and may be triggers and
effectors of cell death. Mitochondrial respiration is tightly controlled by the matrix Ca2+ …

Cardiomyocytes are one of the most mitochondria-rich cell types in the body, with∼ 30–40%
of the cell volume being composed of mitochondria. Mitochondria are well established as …

Mitochondria are strategically and dynamically positioned in the cell to spatially coordinate
ATP production with energy needs and to allow the local exchange of material with other …

Cardiac tissue requires a persistent production of energy in order to exert its pumping
function. Therefore, the maintenance of this function relies on mitochondria that represent …

Ca2+ signaling is of vital importance to cardiac cell function and plays an important role in
heart failure. It is based on sarcolemmal, sarcoplasmic reticulum and mitochondrial Ca2+ …

The processes of excitation–contraction (EC) coupling consume large amounts of energy
that need to be replenished by oxidative phosphorylation in the mitochondria. Since Ca2+ …

Mitochondrial dysfunction has been implicated in the development of heart failure. Oxidative
metabolism in mitochondria is the main energy source of the heart, and the inability to …

Mitochondria are equipped with efficient machinery for Ca2+ uptake and extrusion and are
capable of storing large amounts of Ca2+ ions. Furthermore, key steps of mitochondrial …