[图书][B] Knottins are a new family of secreted virulence factors that are required for the virulence of the intracellular fungal pathogen Histoplasma capsulatum

RA Rodriguez - 2023 - search.proquest.com
Intracellular pathogens have developed strategies like secreting virulence factors to aid in
replication and survival. Histoplasma capsulatum (Hc) is a thermally dimorphic human …

[图书][B] Histoplasma capsulatum secretes cysteine-rich protein virulence factors to lyse host macrophages

D Azimova - 2021 - search.proquest.com
Intracellular pathogens secrete effectors to manipulate their host cells. Histoplasma
capsulatum (Hc) is a fungal intracellular pathogen of humans that grows in a yeast form in …

The interface between virulence and host response to the pathogenic fungus Histoplasma capsulatum

WA Szymczak, GS Deepe Jr, MS Winters - Current Fungal Infection …, 2008 - Springer
Intracellular pathogens have evolved machinery to evade the immune response in order to
survive within a host. Histoplasma capsulatum, one of the intracellular pathogens, is a …

The transcription factor CHOP, an effector of the integrated stress response, is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatum

BC English, N Van Prooyen, T Örd, T Örd, A Sil - PLoS pathogens, 2017 - journals.plos.org
The ability of intracellular pathogens to manipulate host-cell viability is critical to successful
infection. Some pathogens promote host-cell survival to protect their replicative niche …

Future of Functional Genomics of Histoplasma capsulatum

A Sil, L Hwang - Molecular principles of fungal pathogenesis, 2006 - Wiley Online Library
This chapter describes (i) the previous use of functional genomics in Histoplasma
capsulatum,(ii) the current status of genome‐sequencing projects for this organism,(iii) …

In Silico Analysis of a Drosophila Parasitoid Venom Peptide Reveals Prevalence of the Cation–Polar–Cation Clip Motif in Knottin Proteins

J Arguelles, J Lee, LV Cardenas, S Govind, S Singh - Pathogens, 2023 - mdpi.com
As generalist parasitoid wasps, Leptopilina heterotoma are highly successful on many
species of fruit flies of the genus Drosophila. The parasitoids produce specialized multi …

Pathogenicity & virulence of Histoplasma capsulatum - A multifaceted organism adapted to intracellular environments

AF Valdez, DZ Miranda, AJ Guimarães, L Nimrichter… - Virulence, 2022 - Taylor & Francis
Histoplasmosis is a systemic mycosis caused by the thermally dimorphic fungus
Histoplasma capsulatum. Although healthy individuals can develop histoplasmosis, the …

Revisiting old friends: Developments in understanding Histoplasma capsulatum pathogenesis

JP Woods - Journal of microbiology, 2016 - Springer
Histoplasma capsulatum is a dimorphic pathogenic fungus and causative agent of
histoplasmosis, which is a respiratory and systemic infection that is particularly severe in …

Molecular diversity of fungal inhibitor cystine knot peptides evolved by domain repeat and fusion

J Zhao, S Yuan, B Gao, S Zhu - FEMS microbiology letters, 2018 - academic.oup.com
Peptides with the inhibitor cystine knot (ICK) motif are extensively present in animals and
plants where they exert a diversity of biological functions. However, few studies have been …

Surface Architecture of Histoplasma Capsulatum

AJ Guimaraes, MD de Cerqueira… - Frontiers in …, 2011 - frontiersin.org
The dimorphic fungal pathogen Histoplasma capsulatum is the most frequent cause of
clinically significant fungal pneumonia in humans. H. capsulatum virulence is achieved, in …