Precise patterns of gene expression in metazoans are controlled by three classes of
regulatory elements: promoters, enhancers and boundary elements. During differentiation …

The precise regulation of gene transcription during metazoan development is controlled by a
complex system of interactions between transcription factors, histone modifications and …

The relationships among in vivo chromatin structures, chromosome organization and
genome function must be understood in order to reveal the hidden regulatory information in …

Cell type specific transcriptional regulation must be adhered to in order to maintain cell
identity throughout the lifetime of an organism, yet it must be flexible enough to allow for …

Regulation of gene expression involves a number of different levels of organization in the
cell nucleus. The main agents of transcriptional control are the cis-acting sequences in the …

Much of what we know about the chromatin-based mechanisms that regulate gene
expression in mammals has come from the study of what are, paradoxically, atypical genes …

The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

It is now well accepted that cell-type specific gene regulation is under the purview of
enhancers. Great strides have been made recently to characterize and identify enhancers …

Compartmentalization and compaction of DNA in the nucleus is the characteristic feature of
eukaryotic cells. A fully extended DNA molecule has to be compacted 100,000 times to fit …

Chromatin is the most complex supramolecular organization of the cell. It has a dual role: to
compact the chromosomal DNA and to ensure a highly efficient regulation of gene …