Hepatitis C virus (HCV) causes chronic infection accompanied by a high risk of liver failure
and hepatocellular carcinoma. CD8+ T cell responses are important in the control of viremia …

Costimulatory signals via B7/CD28 family molecules (signal 2) are critical for effective
adaptive CD8+ T cell immune responses. In addition to costimulatory signals, B7/CD28 …

CD4 T‐cell function is crucial for the eradication of HCV, and insufficient function is observed
in chronic carriers. The monitoring of T‐cell responses is complicated by the scarcity of …

The majority of people infected with hepatitis C virus (HCV) fail to generate or maintain a T-
cell response effective for viral clearance. Evidence from murine chronic viral infections …

BACKGROUND & AIMS: Virus-specific CD4+ T cells play a major role in hepatitis C virus
(HCV) infection. Viral clearance is associated with vigorous and multispecific CD4+ T cell …

Background & Aims Spontaneous resolution of hepatitis C virus (HCV) infection depends
upon a broad T cell response to multiple viral epitopes. However, most patients fail to clear …

Hepatitis C virus (HCV) is one of the main causes of chronic liver disease. Although infection
of hepatocytes is mainly responsible for manifestations of hepatitis C, the virus also invades …

It is believed that the hepatitis C virus (HCV)-specific CD8+ cytotoxic T lymphocytes (CTLs)
play a role in the development of liver cell injury and in the clearance of the virus. To …

Background/Aims: Association of hepatitis C virus (HCV) with increased autoantibodies,
mixed cryoglobulinaemia, non-Hodgkin's B-cell lymphoma and increased peripheral innate …

BACKGROUND & AIMS: Hepatitis C virus (HCV) is remarkably successful in establishing
persistent infections due to its ability to evade host immune responses through a …