Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
Lung cancer often has a poor prognosis, with brain metastases a major reason for mortality.
We modified lonidamine (LND), an antiglycolytic drug with limited efficacy, to mitochondria …
We modified lonidamine (LND), an antiglycolytic drug with limited efficacy, to mitochondria …
A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission
J Zhou, G Li, Y Zheng, HM Shen, X Hu, QL Ming… - Autophagy, 2015 - Taylor & Francis
Autophagy inhibition has been widely accepted as a promising therapeutic strategy in
cancer, while the lack of effective and specific autophagy inhibitors hinders its application …
cancer, while the lack of effective and specific autophagy inhibitors hinders its application …
Inhibition of mitochondrial complex II by the anticancer agent lonidamine
The antitumor agent lonidamine (LND; 1-(2, 4-dichlorobenzyl)-1H-indazole-3-carboxylic
acid) is known to interfere with energy-yielding processes in cancer cells. However, the …
acid) is known to interfere with energy-yielding processes in cancer cells. However, the …
Targeting mitochondria for cancer therapy
S Fulda, L Galluzzi, G Kroemer - Nature reviews Drug discovery, 2010 - nature.com
Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of
lethal signal transduction pathways converge on mitochondria to cause the permeabilization …
lethal signal transduction pathways converge on mitochondria to cause the permeabilization …
Mitochondrial-targeting lonidamine-doxorubicin nanoparticles for synergistic chemotherapy to conquer drug resistance
Lonidamine (LND) can act on mitochondria and inhibit energy metabolism in cancer cells
and therefore has been used together with chemotherapy drugs for synergistically enhanced …
and therefore has been used together with chemotherapy drugs for synergistically enhanced …
Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
The molecular mode of action of lonidamine, a therapeutic agent employed in cancer
chemotherapy, has been elusive. Here we provide evidence that lonidamine (LND) acts on …
chemotherapy, has been elusive. Here we provide evidence that lonidamine (LND) acts on …
The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters
Lonidamine (LND) is an anti-tumour drug particularly effective at selectively sensitizing
tumours to chemotherapy, hyperthermia and radiotherapy, although its precise mode of …
tumours to chemotherapy, hyperthermia and radiotherapy, although its precise mode of …
Autophagy promotes BrafV600E-driven lung tumorigenesis by preserving mitochondrial metabolism
AM Strohecker, E White - Autophagy, 2014 - Taylor & Francis
The role of autophagy in cancer is complex and context-dependent. Here we describe work
with genetically engineered mouse models of non-small cell lung cancer (NSCLC) in which …
with genetically engineered mouse models of non-small cell lung cancer (NSCLC) in which …
Targeting cancer cell mitochondria as a therapeutic approach: recent updates
Mitochondria play a key role in ATP generation, redox homeostasis and regulation of
apoptosis. Due to the essential role of mitochondria in metabolism and cell survival …
apoptosis. Due to the essential role of mitochondria in metabolism and cell survival …
Treatment strategies that enhance the efficacy and selectivity of mitochondria-targeted anticancer agents
JS Modica-Napolitano, V Weissig - International journal of molecular …, 2015 - mdpi.com
Nearly a century has passed since Otto Warburg first observed high rates of aerobic
glycolysis in a variety of tumor cell types and suggested that this phenomenon might be due …
glycolysis in a variety of tumor cell types and suggested that this phenomenon might be due …