Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder

MN Hill, P Campolongo, R Yehuda… - …, 2018 - nature.com
Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

Translational evidence for a role of endocannabinoids in the etiology and treatment of posttraumatic stress disorder

A Neumeister, J Seidel, BJ Ragen… - Psychoneuroendocrinology, 2015 - Elsevier
Introduction Posttraumatic stress disorder (PTSD) is a prevalent, chronic, and disabling
anxiety disorder that may develop following exposure to a traumatic event. Despite the …

Cannabinoids as therapeutics for PTSD

B Sbarski, I Akirav - Pharmacology & Therapeutics, 2020 - Elsevier
Post-traumatic stress disorder (PTSD) is a complex disorder that involves dysregulation of
multiple neurobiological systems. The traumatic stressor plays a causal role in producing …

Mitigation of post‐traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence

T Passie, HM Emrich, M Karst, SD Brandt… - Drug testing and …, 2012 - Wiley Online Library
It is known from clinical studies that some patients attempt to cope with the symptoms of post‐
traumatic stress disorder (PTSD) by using recreational drugs. This review presents a case …

[HTML][HTML] Targeting the endocannabinoid system to treat anxiety-related disorders

N Korem, TM Zer-Aviv, E Ganon-Elazar… - Journal of basic and …, 2016 - degruyter.com
The endocannabinoid system plays an important role in the control of emotions, and its
dysregulation has been implicated in several psychiatric disorders. The most common self …

[HTML][HTML] The endocannabinoid system as a possible target to treat both the cognitive and emotional features of post-traumatic stress disorder (PTSD)

V Trezza, P Campolongo - Frontiers in behavioral neuroscience, 2013 - frontiersin.org
Post-traumatic stress disorder (PTSD) is a psychiatric disorder of significant prevalence and
morbidity, whose pathogenesis relies on paradoxical changes of emotional memory …

Cannabinoid interventions for PTSD: Where to next?

LJ Ney, A Matthews, R Bruno… - Progress in Neuro …, 2019 - Elsevier
Cannabinoids are a promising method for pharmacological treatment of post-traumatic
stress disorder (PTSD). Despite considerable research devoted to the effect of cannabinoid …

Meet your stress management professionals: the endocannabinoids

TA deRoon-Cassini, TM Stollenwerk, M Beatka… - Trends in molecular …, 2020 - cell.com
The endocannabinoid signaling system (ECSS) is altered by exposure to stress and
mediates and modulates the effects of stress on the brain. Considerable preclinical data …

Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders

BB Gorzalka, MN Hill, CJ Hillard - Neuroscience & Biobehavioral Reviews, 2008 - Elsevier
The endocannabinoid system is a widely distributed, neuromodulatory system which serves
an integral role in regulating synaptic transmission. The presence of this system in stress …

Marijuana and other cannabinoids as a treatment for posttraumatic stress disorder: A literature review

MM Steenkamp, EM Blessing… - Depression and …, 2017 - Wiley Online Library
Posttraumatic stress disorder (PTSD) is common in the general population, yet there are
limitations to the effectiveness, tolerability, and acceptability of available first‐line …