Aims: Studies on cancer biology have shown that overexpression of oncogenes (with or
without functional loss of tumor suppressor genes), which is responsible for the progression …

C-myc is an oncogene with the important role of cell proliferation controller. It has been
found to be amplified and overexpressed in osteosarcoma. Moreover, it can promote cell …

Methods Recombinant adenovirus Ad-As-c-myc encoding antisense c-myc was constructed
by gene reconstruction technique, defined by polymerase chain reaction (PCR), and …

Osteosarcoma is the most common form of primary malignant bone tumor. Patients who are
insensitive to chemotherapy treatment often have a poor prognosis. According to our …

The present study was performed to investigate whether the introduction of a wild-type p53
gene into human osteosarcoma cells could alter the growth rate and enhance the cytocidal …

Abstract Background/Aims: Overexpression of the c-myc oncogene frequently occurs in both
colon tumors and colon carcinoma cell lines. We examined the sensitization of human …

Human colon cancer SW480 cells express the c-myc gene. On the other hand, SW480DDP
cell lines resistant to cisplatin exhibited decreased c-myc gene expression, but their cell …

BACKGROUND: Phosphorothioate oligonucleotides ([S] ODNs) contain a modified
phosphate backbone. Antisense [S] ODNs targeted to specific oncogenes have been used …

The aim of this study was to examine the effects of SG511, a novel fiber chimeric oncolytic
adenovirus with E1B 55-kDa deleted, combined with cisplatin on cancer cells and to identify …

Abstract Background and Aims: This study used a recombinant antisense c‐myc adenovirus
(Ad‐ASc‐myc) to evaluate how alterations of c‐myc expression in the SGC7901 human …