Pumps and the new pills

EJ Birks, A Kolodziej - ASAIO Journal, 2020 - journals.lww.com
single-center study that the short-term use of tolvaptan following LVAD implantation is a safe
and effective therapy to augment diuresis and improve hyponatremia. Their analysis …

Short-term efficacy and safety of tolvaptan in patients with left ventricular assist devices

T Fujino, T Imamura, A Nguyen, B Chung… - ASAIO …, 2020 - journals.lww.com
Tolvaptan is an effective therapy for heart failure patients with symptomatic congestion and
hyponatremia. The efficacy of its use in patients with continuous-flow left ventricular assist …

Postoperative tolvaptan use in left ventricular assist device patients: The TOLVAD randomized pilot study

MN Belkin, T Imamura, D Rodgers, AJ Kanelidis… - Artificial …, 2022 - Wiley Online Library
Purpose Tolvaptan, a selective vasopressin type‐2 antagonist, has been shown to increase
serum sodium (Na) and urine output in hyponatremic left ventricular assist device (LVAD) …

Correction of hyponatremia by tolvaptan before left ventricular assist device implantation

T Imamura, K Kinugawa, T Shiga, N Kato… - International Heart …, 2012 - jstage.jst.go.jp
Hypervolemic hyponatremia is often complicated with advanced heart failure together with
increased excretion of sodium by diuretics. Tolvaptan, an oral vasopressin-2-receptor …

Efficacy and Safety of Tolvaptan in Heart Failure Patients With Volume Overload–An Interim Result of Post-Marketing Surveillance in Japan–

K Kinugawa, N Sato, T Inomata, T Shimakawa… - Circulation …, 2014 - jstage.jst.go.jp
Background: Loop diuretics are commonly used in heart failure (HF) patients, but they are
sometimes associated with insufficient response as well as adverse events. In such diuretics …

Benefit of tolvaptan in the management of hyponatraemia in patients with diuretic‐refractory congestive heart failure: the SEMI‐SEC project

A Pose, L Almenar, JJ Gavira… - ESC heart …, 2017 - Wiley Online Library
Aims Hyponatraemia is an electrolyte disorder that occurs in advanced congestive heart
failure (HF) and worsens prognosis. We explored the usefulness of tolvaptan, which has …

Urine Sodium Excretion After Tolvaptan Administration Is Dependent Upon Baseline Serum Sodium Levels A Possible Explanation for the Improvement of …

T Imamura, K Kinugawa, S Minatsuki… - International Heart …, 2014 - jstage.jst.go.jp
Several studies have demonstrated that tolvaptan (TLV) can improve hyponatremia in
advanced heart failure (HF) patients with rare chance of hypernatremia. However, changes …

Hyponatremia, heart failure, and the role of tolvaptan

JB O'Connell, A Alemayehu - Postgraduate Medicine, 2012 - Taylor & Francis
Hyponatremia–usually defined by serum sodium< 135 mEq/L–is common in heart failure
(HF); it remains unclear whether it worsens HF or is merely a marker of more severe …

Does Tolvaptan Have Any Therapeutic Roles in Patients With Left Ventricular Assist Device?

T Imamura - ASAIO Journal, 2019 - journals.lww.com
The survival rate in patients with advanced heart failure has improved owing to the
development of left ventricular assist devices (LVADs), which improves patients' …

Urine osmolality-guided tolvaptan therapy in decompensated heart failure

K Dohi, K Watanabe, M Ito - Circulation Journal, 2013 - jstage.jst.go.jp
Although the authors emphasize that the non-invasively estimated cardiac index, right
ventricular systolic pressure, and pulmonary wedge pressure values obtained from …