Peptide–Polymer Conjugates: A Promising Therapeutic Solution for Drug‐Resistant Bacteria

X Shen, Y Zhang, Q Mao, Z Huang… - … Journal of Polymer …, 2022 - Wiley Online Library
By 2050, it is estimated that 10 million people will die of drug‐resistant bacterial infection
caused by antibiotic abuse. Antimicrobial peptide (AMP) is widely used to prevent such …

Synthesis, self-assembly, and biomedical applications of antimicrobial peptide–polymer conjugates

H Sun, Y Hong, Y Xi, Y Zou, J Gao, J Du - Biomacromolecules, 2018 - ACS Publications
Antimicrobial peptides (AMPs) have been attracting much attention due to their excellent
antimicrobial efficiency and low rate in driving antimicrobial resistance (AMR), which has …

Molecular engineering of antimicrobial peptide (AMP)–polymer conjugates

Z Cui, Q Luo, MS Bannon, VP Gray, TG Bloom… - Biomaterials …, 2021 - pubs.rsc.org
As antimicrobial resistance becomes an increasing threat, bringing significant economic and
health burdens, innovative antimicrobial treatments are urgently needed. While antimicrobial …

Antimicrobial Peptide–Polymer Conjugates

M Riool, V Patrulea, C Monteiro - Pharmaceutics, 2022 - mdpi.com
The global health threat imposed by the fast spread of antibiotic-resistant bacteria is
directing research not only towards the discovery of new antibacterial molecules but also to …

AMP-Mimetic Antimicrobial Polymer-Involved Synergic Therapy with Various Coagents for Improved Efficiency

Y Gong, H Wang, J Sun - Biomacromolecules, 2024 - ACS Publications
The misuse of antibiotics contributes to the emergence of multidrug-resistant (MDR)
bacteria. Infections caused by MDR bacteria are rapidly evolving into a significant threat to …

Recent advances in the design of antimicrobial peptide conjugates

ARP Silva, MS Guimarães, J Rabelo… - Journal of Materials …, 2022 - pubs.rsc.org
Antimicrobial peptides (AMPs) are ubiquitous host defense peptides characterized by their
antibiotic activity and lower propensity for developing resistance compared to classic …

Antibiotics-peptide conjugates against multidrug-resistant bacterial pathogens

AA David, SE Park, K Parang… - Current Topics in …, 2018 - ingentaconnect.com
The menace of multi-drug resistance by bacterial pathogens that are responsible for
infectious diseases in humans and animals cannot be over-emphasized. Many bacteria …

Antimicrobial peptide–polymer conjugates with high activity: Influence of polymer molecular weight and peptide sequence on antimicrobial activity, proteolysis, and …

P Kumar, A Takayesu, U Abbasi… - … applied materials & …, 2017 - ACS Publications
We report the synthesis, characterization, activity, and biocompatibility of a novel series of
antimicrobial peptide–polymer conjugates. Using parent peptide aurein 2.2, we designed a …

How can biomaterial-conjugated antimicrobial peptides fight bacteria and be protected from degradation?

PM Alves, CC Barrias, P Gomes, MCL Martins - Acta Biomaterialia, 2024 - Elsevier
The emergence of antibiotic-resistant bacteria is a serious threat to public health.
Antimicrobial peptides (AMP) are a powerful alternative to antibiotics due to their low …

Synthetic random copolymers as a molecular platform to mimic host-defense antimicrobial peptides

H Takahashi, GA Caputo, S Vemparala… - Bioconjugate …, 2017 - ACS Publications
Synthetic polymers have been used as a molecular platform to develop host-defense
antimicrobial peptide (AMP) mimetics which are effective in killing drug-resistant bacteria. In …