Mortality from liver disease conditions continues to be very high. As liver diseases manifest
and progress silently, prompt measures after diagnosis are essential in the treatment of …

Hepatology and drug development for liver diseases require in vitro liver models. Typical
models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte …

The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …

Physiologically relevant and broadly applicable liver cell culture platforms are of great
importance in both drug development and disease modeling. Organ-on-a-chip systems offer …

To understand disease pathophysiologies, models that recapitulate human functions are
necessary. In vitro models that consist of human cells are preferred to ones using animal …

The design and fabrication of a very large-scale liver-lobule (VLSLL)-on-a-chip device,
providing a microphysiological niche for hepatocytes, is described. The device consists of an …

The liver, the largest organ in the human body, is a multi-functional organ with diverse
metabolic activities that plays a critical role in maintaining the body and sustaining life …

The liver is the largest internal organ in the human body with largest mass of glandular
tissue. Modeling the liver has been challenging due to its variety of major functions …

An organ-on-a-chip is a device that combines micro-manufacturing and tissue engineering
to replicate the critical physiological environment and functions of the human organs …

Drug development is a costly and lengthy process with low success rates. To improve the
efficiency of drug development, there has been an increasing need in developing alternative …