Control interventions steer the evolution of molecules, viruses, microorganisms or other cells
towards a desired outcome. Applications range from engineering biomolecules and …

Feedback loops between population dynamics of individuals and their ecological
environment are ubiquitously found in nature and have shown profound effects on the …

The pace and unpredictability of evolution are critically relevant in a variety of modern
challenges, such as combating drug resistance in pathogens and cancer, understanding …

Control theory arose from a need to control synthetic systems. From regulating steam
engines to tuning radios to devices capable of autonomous movement, it provided a formal …

Living organisms are differentiated by their genetic material-millions to billions of DNA bases
encoding thousands of genes. These genes are translated into a vast array of proteins …

A major goal of biological research is to provide a mechanistic understanding of diverse
biological processes. To this end, synthetic biology offers a powerful approach, whereby …

We, and all organisms, are an evolutionary masterpiece of multiscale feedback control.
Feedback loops enable our cells to grow and then stop at the right size, to divide and self …

Synthetic biology is the application of engineering principles to the fundamental components
of biology, with the aim of creating systems with novel functionalities that can be used for …

Open-ended evolution (OEE) is relevant to a variety of biological, artificial and technological
systems, but has been challenging to reproduce in silico. Most theoretical efforts focus on …

This tutorial article gives an overview of the theory and design tools for the real-time control
of living cells. The theoretical, computational, and experimental tools and technologies …