The histopathological classification of a disease should reflect both current concepts of its
pathogenesis as well as its clinical behavior. Over the last 50 years our understanding of the …

Nine hundred and forty-eight patients with carcinoma in situ (CIS) of the cervix diagnosed
histologically have been followed from five to 28 years. Among the 817 patients who had …

Based on extensive histomorphologic study, a concept of cervical carcinogenesis is
formulated. Intraepithelial neoplasia arises in well defined and predestined fields that are …

The World Health Organization (WHO) classification for tumors of the cervix has been
revised recently in collaboration with the International Society of GynecolOgical …

Squamous cell carcinoma of the cervix fulfills the model for a classic multistage disease
beginning with the acquisition of a precursor lesion, morphologic progression of the …

It is postulated that squamous cell carcinoma, adenocarcinoma, and mixed adenosquamous
cell carcinoma of the uterine cervix all have a common cell or origin, the subcolumnar …

Two hundred cases of early squamous cell carcinoma of the cervix were studied, 109 with
early stromal invasion (ESI)(FIGO stage lal) and 91 microcarcinomas (MCs)(stage Ia2). Nine …

The nomenclature and classification of intraepithelial squamous lesions of the cervix have a
controversial history, 17 now further complicated by the introduction of new terminology for …

The term dysplasia will be used to designate all those lesions thought to precede cervical
cancer not defined by the above definition of CIS. The dysplasias are subdivided into three …

Six cases of carcinoma in situ of the cervix have been observed in this clinic to progress to
invasive cervical cancer in from 11 months to six and one half years. Three of these patients …