Pharmacokinetics of piperacillin and tazobactam in critically Ill patients treated with continuous kidney replacement therapy: A mini‐review and population …
DJ Selig, JP DeLuca, KK Chung… - Journal of Clinical …, 2022 - Wiley Online Library
What is known and objective Timely and appropriate dosing of antibiotics is essential for the
treatment of bacterial sepsis. Critically ill patients treated with continuous kidney …
treatment of bacterial sepsis. Critically ill patients treated with continuous kidney …
Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic …
E Asín-Prieto, A Rodríguez-Gascón… - Journal of …, 2014 - academic.oup.com
Objectives To evaluate the pharmacokinetics of piperacillin/tazobactam in critically ill
patients undergoing continuous renal replacement therapy (CRRT) and to assess the …
patients undergoing continuous renal replacement therapy (CRRT) and to assess the …
Predictive Factors of Piperacillin Exposure and the Impact on Target Attainment after Continuous Infusion Administration to Critically Ill Patients
J Martínez-Casanova, E Esteve-Pitarch… - Antibiotics, 2023 - mdpi.com
Critically ill patients undergo significant pathophysiological changes that affect antibiotic
pharmacokinetics. Piperacillin/tazobactam administered by continuous infusion (CI) …
pharmacokinetics. Piperacillin/tazobactam administered by continuous infusion (CI) …
Pharmacokinetics of an extended 4‐hour infusion of piperacillin‐tazobactam in critically ill patients undergoing continuous renal replacement therapy
DK Awissi, A Beauchamp, E Hébert… - … : The Journal of …, 2015 - Wiley Online Library
Study Objective To evaluate the pharmacokinetic and pharmacodynamic profiles of
piperacillin‐tazobactam administered as a 4‐hour infusion in critically ill patients undergoing …
piperacillin‐tazobactam administered as a 4‐hour infusion in critically ill patients undergoing …
Impact of renal replacement modalities on the clearance of piperacillin-tazobactam administered via continuous infusion in critically ill patients
C Roger, MO Cotta, L Muller, SC Wallis… - International Journal of …, 2017 - Elsevier
This prospective pharmacokinetic study aimed to compare the clearance of piperacillin-
tazobactam administered as a 24-h continuous infusion between continuous venovenous …
tazobactam administered as a 24-h continuous infusion between continuous venovenous …
An integral pharmacokinetic analysis of piperacillin and tazobactam in plasma and urine in critically ill patients
E Wallenburg, R Ter Heine, JA Schouten… - Clinical …, 2022 - Springer
Abstract Background and Objectives Although dose optimization studies have been
performed for piperacillin and tazobactam separately, a combined integral analysis is not yet …
performed for piperacillin and tazobactam separately, a combined integral analysis is not yet …
Population pharmacokinetics of piperacillin following continuous infusion in critically ill patients and impact of renal function on target attainment
V Klastrup, A Thorsted, M Storgaard… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Pharmacokinetic changes are often seen in patients with severe infections. Administration
by continuous infusion has been suggested to optimize antibiotic exposure and …
by continuous infusion has been suggested to optimize antibiotic exposure and …
Higher than standard dosing regimen are needed to achieve optimal antibiotic exposure in critically ill patients with augmented renal clearance receiving piperacillin …
C Carrie, R Legeron, L Petit, J Ollivier, V Cottenceau… - Journal of critical …, 2018 - Elsevier
Purpose To determine whether augmented renal clearance (ARC) impacts negatively on
piperacillin-tazobactam unbound concentrations in critically ill patients receiving 16 g/2 …
piperacillin-tazobactam unbound concentrations in critically ill patients receiving 16 g/2 …
A population pharmacokinetics and pharmacodynamic approach to optimize tazobactam activity in critically ill patients
SN Kalaria, M Gopalakrishnan… - Antimicrobial agents and …, 2020 - Am Soc Microbiol
The percentage of the time that the free drug concentration remains above a concentration
threshold (% fT> concentration threshold) has frequently been identified to be the optimal …
threshold (% fT> concentration threshold) has frequently been identified to be the optimal …
Pharmacokinetics and outcome of tazobactam/piperacillin in Japanese patients undergoing low-flow continuous renal replacement therapy: dosage considerations
H Kohama, T Ide, K Ikawa, N Morikawa… - Clinical pharmacology …, 2017 - Taylor & Francis
Background Tazobactam/piperacillin (TAZ/PIPC), which is often combined with continuous
renal replacement therapy (CRRT), induces renal excretion and is thought to have a high …
renal replacement therapy (CRRT), induces renal excretion and is thought to have a high …
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