The nature and dynamics of spermatogonial stem cells

DG De Rooij - Development, 2017 - journals.biologists.com
Spermatogonial stem cells (SSCs) are crucial for maintaining spermatogenesis throughout
life, and understanding how these cells function has important implications for …

A revised Asingle model to explain stem cell dynamics in the mouse male germline

T Lord, JM Oatley - Reproduction, 2017 - rep.bioscientifica.com
Spermatogonial stem cells (SSCs) and progenitor spermatogonia encompass the
undifferentiated spermatogonial pool in mammalian testes. In rodents, this population is …

Molecular regulation of spermatogonial stem cell renewal and differentiation

JA Mäkelä, RM Hobbs - Reproduction, 2019 - rep.bioscientifica.com
The intricate molecular and cellular interactions between spermatogonial stem cells (SSCs)
and their cognate niche form the basis for life-long sperm production. To maintain long-term …

A single-cell view of spermatogonial stem cells

K Tan, MF Wilkinson - Current opinion in cell biology, 2020 - Elsevier
Spermatogonial stem cells (SSCs) are essential for long-term spermatogenesis and are the
subject of considerable clinical interest, as 'SSC therapy'has the potential to cure some …

Spermatogonial stem cell regulation and spermatogenesis

BT Phillips, K Gassei, KE Orwig - … Transactions of the …, 2010 - royalsocietypublishing.org
This article will provide an updated review of spermatogonial stem cells and their role in
maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial …

Open niche regulation of mouse spermatogenic stem cells

S Yoshida - Development, growth & differentiation, 2018 - Wiley Online Library
In mammalian testes, robust stem cell functions ensure the continual production of sperm. In
testicular seminiferous tubules, spermatogenic stem cells (SSC s) are highly motile and are …

Mechanisms regulating mammalian spermatogenesis and fertility recovery following germ cell depletion

HM La, RM Hobbs - Cellular and Molecular Life Sciences, 2019 - Springer
Mammalian spermatogenesis is a highly complex multi-step process sustained by a
population of mitotic germ cells with self-renewal potential known as spermatogonial stem …

Spermatogonial stem cells: updates from specification to clinical relevance

S Sharma, J Wistuba, T Pock, S Schlatt… - Human reproduction …, 2019 - academic.oup.com
Human spermatogonia are target for exploration of adult stem cell characteristics and
potential source for the development of therapeutic applications. Almost 50 years ago, Yves …

Identification of spermatogonial stem cell subsets by morphological analysis and prospective isolation

L Grisanti, I Falciatori, M Grasso, L Dovere, S Fera… - Stem …, 2009 - academic.oup.com
Spermatogenesis is maintained by a pool of spermatogonial stem cells (SSCs). Analyses of
the molecular profile of SSCs have revealed the existence of subsets, indicating that the …

Molecular dissection of the male germ cell lineage identifies putative spermatogonial stem cells in rhesus macaques

BP Hermann, M Sukhwani, DR Simorangkir… - Human …, 2009 - academic.oup.com
BACKGROUND The spermatogonial stem cell (SSC) pool in the testes of non-human
primates is poorly defined. METHODS To begin characterizing SSCs in rhesus macaque …