Mechanisms underlying the antiarrhythmic effect of ARumenamide-787 in experimental models of the J wave syndromes and hypothermia

JM Di Diego, H Barajas-Martinez, R Cox, VM Robinson… - Plos one, 2023 - journals.plos.org
Background Brugada (BrS) and early repolarization syndromes (ERS), the so-called J wave
syndromes (JWS), are associated with life-threatening ventricular arrhythmias …

Acacetin suppresses the electrocardiographic and arrhythmic manifestations of the J wave syndromes

JM Di Diego, B Patocskai, H Barajas-Martinez… - PloS one, 2020 - journals.plos.org
Background J wave syndromes (JWS), including Brugada (BrS) and early repolarization
syndromes (ERS), are associated with increased risk for life-threatening ventricular …

J wave syndromes: What's new?

C Antzelevitch, JM Di Diego - Trends in cardiovascular medicine, 2022 - Elsevier
Among the inherited ion channelopathies associated with potentially life-threatening
ventricular arrhythmia syndromes in nominally structurally normal hearts are the J wave …

J-wave syndromes: Brugada and early repolarization syndromes

C Antzelevitch, GX Yan - Heart Rhythm, 2015 - Elsevier
A prominent J wave is encountered in a number of life-threatening cardiac arrhythmia
syndromes, including the Brugada syndrome and early repolarization syndromes. Brugada …

J wave syndromes as a cause of malignant cardiac arrhythmias

JM Di Diego, C Antzelevitch - Pacing and Clinical …, 2018 - Wiley Online Library
The J wave syndromes, including the Brugada (BrS) and early repolarization (ERS)
syndromes, are characterized by the manifestation of prominent J waves in the …

History of the J wave and J wave syndromes

I Gussak, G Gussak - J Wave Syndromes: Brugada and Early …, 2016 - Springer
Since discovery of the Brugada syndrome, ECG phenomena of late ventricular
depolarization and early ventricular repolarization has rapidly gained recognition as a major …

J-Wave syndromes expert consensus conference report: emerging concepts and gaps in knowledge

C Antzelevitch, GX Yan, MJ Ackerman, M Borggrefe… - Europace, 2017 - academic.oup.com
The J-wave syndromes (JWSs), consisting of the Brugada syndrome (BrS) and early
repolarization syndrome (ERS), have captured the interest of the cardiology community over …

[HTML][HTML] Brugada syndrome and early repolarization syndrome: cellular basis and clinical features

GB Nam - Journal of Arrhythmia, 2013 - Elsevier
Brugada syndrome (BS) and early repolarization syndrome (ERS) are newly introduced
electrical disorders responsible for ventricular fibrillation (VF) and sudden cardiac death in …

[HTML][HTML] Concomitant SK current activation and sodium current inhibition cause J wave syndrome

M Chen, DZ Xu, AZ Wu, S Guo, J Wan, D Yin, SF Lin… - JCI insight, 2018 - ncbi.nlm.nih.gov
The mechanisms of J wave syndrome (JWS) are incompletely understood. Here, we showed
that the concomitant activation of small-conductance calcium-activated potassium (SK) …

Inhibition of cardiac Kv1. 5 and Kv4. 3 potassium channels by the class Ia anti-arrhythmic ajmaline: mode of action

F Fischer, N Vonderlin, E Zitron, C Seyler… - Naunyn-Schmiedeberg's …, 2013 - Springer
Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of
Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. For ajmaline …