Alzheimer's disease (AD) affects more than 40 million people worldwide and is the leading
cause of dementia. This disease is a challenge for both patients and caregivers and puts a …

Elevated pulse pressure can cause blood-brain barrier dysfunction and subsequent adverse
neurological changes that may drive or contribute to the development of dementia with age …

Objective: Amyloid β (Aβ) deposition is a hallmark of Alzheimer's disease (AD). Aβ is
generated via enzymatic cleavage of amyloid precursor protein (APP). Increased APP …

Type 2 diabetes mellitus (T2D) is a significant global public health problem that has seen a
substantial increase in the number of affected individuals in recent decades. In a murine …

Given the unprecedented rise in the world's population, the prevalence of prominent age-
related disorders, like cardiovascular disease and dementia, will further increase. Recent …

Importance Increased pulse pressure associated with age-related arterial stiffening
increases risk for Alzheimer dementia but the mechanism responsible for this association …

Arterial stiffness is emerging as an important risk marker for poor brain aging and dementia
through its associations with cerebral small vessel disease, stroke, β-amyloid deposition …

Large artery stiffness is a frequent condition that arises with ageing, and is accelerated by
the presence of co‐morbidities like hypertension, obesity and diabetes. Although …

Background Advances in PET imaging using amyloid specific ligands (eg PiB-PET) provide
in vivo measurement of amyloid deposition in the brain, a hallmark of Alzheimer's disease …

Alzheimer's disease (AD) has long been considered a brain-specific dementia syndrome.
However, in recent decades, the occurrence of cardiovascular (CV) disease in the …