Natural products are an important source of new drugs for the treatment of various diseases.
However, developing natural product-based new medicines through random moiety …

Natural and traditional medicines, being a great source of drugs and drug leads, have
regained wide interests due to the limited success of high-throughput screening of …

Covering: up to February 2016 Identification of the target proteins of natural products is
pivotal to understanding the mechanisms of action to develop natural products for use as …

Chemical genetics and reverse chemical genetics parallel classical genetics but target
genes at the protein level and have proven useful in recent years for screening …

In the modern process of drug discovery, clinical, functional and chemical proteomics can
converge and integrate synergies. Functional proteomics explores and elucidates the …

Natural products continue to be an unparalleled source of pharmacologically active lead
compounds because of their unprecedented structures and unique biological activities …

Phenotype-based drug discovery is a key strategy for small molecule drug screening, and
the molecular target identification of small molecules, termed “target deconvolution,” is …

Background: The field of proteomics aims to characterize dynamics in protein function on a
global level. However, several classes of proteins, in particular low abundance proteins …

Chemical probes represent versatile tools to validate disease-modifying targets. However,
evaluating the selectivity of chemical probes in complex cellular systems is a major …

Covering: 2010 up to 2016 Deconvoluting the mode of action of natural products and drugs
remains one of the biggest challenges in chemistry and biology today. Chemical proteomics …