Colorectal cancer (CRC) is a major health burden worldwide and is the third most common
type of cancer. The early detection and diagnosis of CRC is critical to improve patient …

Colorectal cancer (CRC) is a major cause of mortality in western society with a 5-year
survival of approximately 50%. Metastasis to the liver and lungs is the principal cause of …

Colorectal cancer is the second leading cause of cancer-related mortality in the United
States. Therapeutic developments in the past decade have extended life expectancy in …

Cancer comprises epithelial tumor cells and associated stroma, often times referred to as the
“tumoral microenvironment”. Cancer-associated fibroblasts (CAFs) are the most notable …

Cytokines are a family of soluble factors (Growth Factors (GFs), chemokines, angiogenic
factors, and interferons), which regulate a wide range of mechanisms in both physiological …

Colorectal cancer (CRC) is a heterogeneous disease, with variable molecular pathogenesis
and responses to treatments. About 40–50% of patients with locally advanced CRC exhibit …

Colorectal cancer is the third most common form of cancer worldwide leading to escalating
mortality rates and mainly includes hereditary, sporadic and colitis-associated cancer …

Experimental studies and analyses of clinical material have convincingly demonstrated that
tumor formation and progression occurs through a concerted action of malignant cells and …

Colorectal cancer (CRC) remains the third most prevalent cancer disease and involves a
multi-step process in which intestinal cells acquire malignant characteristics. It is well …

Colorectal cancer (CRC) is one of the most devastating diseases that accounts for numerous
deaths worldwide. Tumor cell-autonomous pathways, such as the oncogenic signaling …