The importance of pain management lies in the fact that it is one of the most common acute
symptoms and, therefore, one of the most common complaints. Primarily, it protects the …

Aim Fentanyl pharmacokinetics and pharmacodynamics are lacking in preterm infants. Our
aim was to study these and their relation with a new formulation of fentanyl 5 μg/mL for …

Fentanyl and its derivatives sufentanil, alfentanil, and remifentanil are potent opioids. A
comprehensive review of the use of fentanyl and its derivatives in the pediatric population …

The data on fentanyl pharmacokinetics in neonates reported by Koehntop et al.(1) exhibit
considerable variability. The coefficients of variation [standard deviation/mean] x 100% of …

In the United States from 2013 to 2019, the nonmethadone synthetic opioid–involved death
rate increased 1040%, from 1.0 to 11.4 per 100 000 (age adjusted), with 51.5% of all 2019 …

Analgesic and sedative drugs are mostly used in an “off label” fashion in children. The
pharmacokinetic-pharmacodymamic (PK/PD) approach is useful in order to determine the …

Aims: Fentanyl is a potent opioid analgesic used within the hospital setting for the
management of acute pain within children following surgical procedures. The dosing of …

A paper on population pharmacokinetics (PK), pharmacogenetics (PGx) and
pharmacodynamics (PD) of fentanyl in preterm neonates undergoing a skin-breaking …

Abstract Background and Objectives Fentanyl is a synthetic opioid commonly used as an
anesthetic and also increasingly popular as a sedative agent in neonates. Initial dosage …

Introduction Fentanyl is a frequently used analgesic in the neonatal intensive care unit
(NICU). Its minimal effect on hemodynamic stability, and its apparent exemption from the …