Clinically, chronic pain and hyperalgesia induced by muscle injury are disabling and difficult
to treat. Cellular and molecular mechanisms underlying chronic muscle-induced …

Acid-sensing ion channels (ASICs) respond to acidosis that normally occurs after
inflammation. We examined the expression of ASIC1, ASIC2, and ASIC3 mRNAs in lumbar …

The acid sensing ion channel 3 (ASIC3) is critical for the development of secondary
hyperalgesia as measured by mechanical stimulation of the paw following muscle insult. We …

Peripheral initiators of muscle pain are virtually unknown, but likely key to development of
chronic pain after muscle insult. The current study tested the hypothesis that ASIC3 in …

BACKGROUND AND PURPOSE Inflammatory pain is triggered by activation of pathways
leading to the release of mediators such as bradykinin, prostaglandins, interleukins, ATP …

An acute bout of exercise can exacerbate pain, hindering participation in regular exercise
and daily activities. The mechanisms underlying pain in response to acute exercise are …

Background: Tissue acidosis is effective in causing chronic muscle pain. However, how
muscle nociceptors contribute to the transition from acute to chronic pain is largely unknown …

Molecular and behavioral evidence suggests that acid-sensing ion channels (ASICs)
contribute to pain processing, but an understanding of their precise role remains elusive …

Acid‐sensing ion channels (ASICs) are cationic channels activated by extracellular acidosis
that are expressed in both central and peripheral nervous systems. Although peripheral …

Acid-sensing ion channels (ASICs) are activated by a decrease in extracellular pH. ASICs
are expressed in nociceptive sensory neurons, and several lines of evidence suggest that …