[HTML][HTML] Cancer and aging: two tightly interconnected biological processes

L Berben, G Floris, H Wildiers, S Hatse - Cancers, 2021 - mdpi.com
Simple Summary As life expectancy is increasing, the older population is rapidly growing.
However, older patients with cancer are still underrepresented in clinical trials, making …

The biology of aging and cancer: frailty, inflammation, and immunity

X Zhang, X Meng, Y Chen, SX Leng… - The Cancer Journal, 2017 - journals.lww.com
The majority of patients with common malignancies are older adults. Intrinsic complex
biological changes of aging along with inflammation, immunosenescence, age-associated …

How ageing processes influence cancer

JP De Magalhães - Nature Reviews Cancer, 2013 - nature.com
The ageing of populations worldwide is leading to an unprecedented increase in cancer
cases and fatalities. Understanding the links between cancer and ageing is therefore more …

[HTML][HTML] Cancer treatment-induced accelerated aging in cancer survivors: biology and assessment

S Wang, A Prizment, B Thyagarajan, A Blaes - Cancers, 2021 - mdpi.com
Simple Summary Many modalities used to treat or control cancer lead to accelerated aging
in cancer survivors. However, the effects of cancer treatments on aging in individuals with …

Geriatric oncology: a clinical approach to the older patient with cancer

L Repetto, A Venturino, L Fratino, D Serraino… - European Journal of …, 2003 - Elsevier
Due to the ageing of the population and the sharp increase in life expectancy, cancer in the
older person has become an increasingly common problem in the Western world. Although …

[HTML][HTML] Biological and functional biomarkers of aging: definition, characteristics, and how they can impact everyday cancer treatment

G Colloca, B Di Capua, A Bellieni, D Fusco… - Current Oncology …, 2020 - Springer
Abstract Purpose of Review Recognize which are the elements that predict why a person is
aging faster or slower and which intervention we can arrange to slow down the process …

[HTML][HTML] Aging, immunity, and cancer

T Fulop, A Larbi, R Kotb, F de Angelis… - Discovery …, 2011 - discoverymedicine.com
Age is the most important risk factor for tumorigenesis. More than 60% of new cancers and
more than 70% of cancer deaths occur in elderly subjects> 65 years. The immune system …

How the ageing microenvironment influences tumour progression

M Fane, AT Weeraratna - Nature Reviews Cancer, 2020 - nature.com
Most cancers arise in individuals over the age of 60. As the world population is living longer
and reaching older ages, cancer is becoming a substantial public health problem. It is …

Considerations for successful cancer immunotherapy in aged hosts

V Hurez, Á Padrón, RS Svatek, TJ Curiel - Experimental Gerontology, 2018 - Elsevier
Improvements in understanding cancer immunopathogenesis have now led to
unprecedented successes in immunotherapy to treat numerous cancers. Although aging is …

The role of immunity in elderly cancer

L Malaguarnera, E Cristaldi, M Malaguarnera - Critical reviews in oncology …, 2010 - Elsevier
The increased incidence of malignancies in elderly patients living in industrialized countries
has led to both identify the causes that alter the normal homeostatic balance in elderly and …