Recent insights into the pathogenesis of pre-eclampsia

JM Roberts, KY Lain - Placenta, 2002 - Elsevier
Pre-eclampsia is more than pregnancy induced hypertension. The emerging view described
in this presentation is that pre-eclampsia is secondary to the interactions of reduced …

Recent insights into the pathophysiology of preeclampsia

EM George, JP Granger - Expert review of obstetrics & gynecology, 2010 - Taylor & Francis
Preeclampsia, characterized by new-onset gestational hypertension and proteinuria, is a
common and serious complication of pregnancy. Evidence from both animal and human …

Preeclampsia: current understanding of the molecular basis of vascular dysfunction

S Sankaralingam, IA Arenas, MM Lalu… - Expert reviews in …, 2006 - cambridge.org
Preeclampsia is a pregnancy-specific disorder characterised by hypertension and
proteinuria occurring after the 20th week of gestation. Delivery of the placenta results in …

Pathophysiology of hypertension in pre‐eclampsia: a lesson in integrative physiology

AC Palei, FT Spradley, JP Warrington… - Acta …, 2013 - Wiley Online Library
Despite being one of the leading causes of maternal death and a major contributor of
maternal and perinatal morbidity, the mechanisms responsible for the pathogenesis of pre …

Placental ischemia and resultant phenotype in animal models of preeclampsia

B LaMarca, LM Amaral, AC Harmon… - Current hypertension …, 2016 - Springer
Preeclampsia is new onset (or worsening of preexisting) hypertension that occurs during
pregnancy. It is accompanied by chronic inflammation, intrauterine growth restriction …

Vascular dysfunction in preeclampsia

LJ Brennan, JS Morton, ST Davidge - Microcirculation, 2014 - Wiley Online Library
Preeclampsia is a complex disorder which affects an estimated 5% of all pregnancies
worldwide. It is diagnosed by hypertension in the presence of proteinuria after the 20th week …

Preeclampsia: what we know and what we do not know

JM Roberts - Seminars in perinatology, 2000 - Elsevier
Preeclampsia remains a major health problem for mothers and infants. Studying the entire
pathophysiology of preeclampsia rather than “pregnancy-induced hypertension” has greatly …

The origins and end-organ consequence of pre-eclampsia

G Eastabrook, M Brown, I Sargent - Best Practice & Research Clinical …, 2011 - Elsevier
Pre-eclampsia is a multisystem disorder with profound implications for both mother and
fetus. Its origins lie in the earliest stages of pregnancy. Abnormal interactions between fetal …

Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction

JP Granger, BT Alexander, MT Llinas, WA Bennett… - …, 2002 - Taylor & Francis
Studies during the past decade have provided a better understanding of the potential
mechanisms responsible for the pathogenesis of preeclampsia. The initiating event in …

Preeclampsia: the role of angiogenic factors in its pathogenesis

A Wang, S Rana, SA Karumanchi - Physiology, 2009 - journals.physiology.org
Preeclampsia, a systemic syndrome of pregnancy clinically characterized by new onset of
proteinuria and hypertension, is associated with significant morbidity and mortality to both …