Background: Major depressive disorder (MDD) is a highly burdensome health condition, for
which there are numerous accepted pharmacological and psychological interventions …

BackgroundDepression is considered to have the highest disability burden of all conditions.
Although treatment-resistant depression (TRD) is a key contributor to that burden, there is …

Objective To compare the efficacy and discontinuation of augmentation agents in adult
patients with treatment-resistant depression (TRD). We conducted a systematic review and …

Objective: To comparatively analyze the efficacy, acceptability, and tolerability of various
augmentation agents in adult patients with treatment-resistant depression. Data Sources: An …

Most interventions for treatment-resistant depression (TRD) are added as augmenters. We
aimed to determine the relative effectiveness of augmentation treatments for TRD. This …

Treatment-resistant depression (TRD) presents many challenges for both patients and
physicians. This review aims to evaluate the current status of the field of TRD and reflects the …

Background Treatment resistant depression (TRD) characterizes a subgroup of 10–30% of
patients with major depressive disorder, and is associated with considerable morbidity and …

OBJECTIVE: To summarize and discuss the conceptual and operational definitions of
treatment resistant/refractory depression (TRD) by systematically reviewing randomized …

Abstract Purpose of Review We review recent advances in the treatment of treatment-
resistant depression (TRD), a disorder with very limited treatment options until recently. We …

Background: Major depressive disorder is a prevalent and disabling illness. Notwithstanding
numerous advances in the pharmacological treatment of depression, approximately 70% of …