A NIR iridium (III) complex-based reversible probe for assessing AD progression and screening anti-AD drugs through visualization of the “Cu2+-H2S seesaw” …

C Liu, M Qin, S Xu, Y Yuan, K Li, J Tang - Sensors and Actuators B …, 2024 - Elsevier
The progression of Alzheimer's disease (AD) is accompanied by the increase of copper ions
(Cu 2+) concentration and decrease of hydrogen sulfide (H 2 S) level in brain tissue, thus …

An efficient biosensor for monitoring Alzheimer's disease risk factors: modulation and disaggregation of the Aβ aggregation process

S Ma, J Qiang, L Li, Y Mo, M She, Z Yang… - Journal of Materials …, 2019 - pubs.rsc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease, which can lead to the
complete loss of cognition. Cu2+ and H2S are both correlated with the physiological and …

A curcumin-based NIR fluorescence probe for detection of amyloid-beta (Aβ) plaques in Alzheimer's disease

G Si, S Zhou, G Xu, J Wang, B Wu, S Zhou - Dyes and Pigments, 2019 - Elsevier
Amyloid-beta (Aβ) peptide as one of the main components of senile plaques is closely
related to the onset and progression of incurable Alzheimer's disease (AD). In recent years …

Multifunctional fluorescence sensor as a potential theranostic agent against Alzheimer's disease

X Kou, X Li, C Hu, J Liu, Y Chen, Y Zhang… - … Acta Part A: Molecular …, 2022 - Elsevier
Metal ions play an important role in the pathogenesis of Alzheimer's disease (AD). Metal
dyshomeostasis, β-amyloid (Aβ) accumulation and oxidative stress, etc. are related to metal …

AND-logic strategy for accurate analysis of Alzheimer's disease via fluorescent probe lighted up by two specific biomarkers

P Zhang, C Fu, H Liu, X Guo, Q Zhang, J Gao… - Analytical …, 2021 - ACS Publications
Alzheimer's disease (AD) has become a global threat to the elderly health with a short
survival time after diagnosis. Due to the asymptomatic stage during the early development …

Unveiling the negative correlation of formaldehyde and hydrogen sulfide in Parkinson's disease models using a dual-responsive ruthenium (II) complex probe

J Ren, W Zhang, X Gao, B Song, J Yuan - Chemical Engineering Journal, 2024 - Elsevier
Parkinson's disease (PD) is one of the most common neurodegenerative diseases caused
by various complicated pathological processes. Recent studies have revealed that …

Dual inhibition and monitoring of beta-amyloid fibrillation by a luminescent iridium (III) complex

CY Wong, LH Chung, L Lu, M Wang… - Current Alzheimer …, 2015 - ingentaconnect.com
In this study, we report the synthesis and application of the novel cyclometallated
luminescent Ir (III) complex 1 bearing the C^ C^ C ligand as a probe and inhibitor of Aβ …

Simultaneous visualization and quantification of copper (II) ions in Alzheimer's disease by a near-infrared fluorescence probe

Z Zhou, S Chen, Y Huang, B Gu, J Li, C Wu… - Biosensors and …, 2022 - Elsevier
The abnormal accumulation of copper ions (Cu 2+) is considered to be one of the
pathological factors of Alzheimer's disease (AD), but the internal relationship between Cu 2+ …

Efficient ratiometric fluorescence probe based on dual-emission luminescent lanthanide coordination polymer for amyloid β-peptide detection

X Liu, X Li, S Xu, S Guo, Q Xue, H Wang - Sensors and Actuators B …, 2022 - Elsevier
As an important biomarker for early Alzheimer's disease (AD) diagnostics and a valuable
therapeutic target, amyloid β peptide (Aβ) in blood has attracted extensive attention …

Aβ plaque-selective NIR fluorescence probe to differentiate Alzheimer's disease from tauopathies

K Rajasekhar, N Narayanaswamy, NA Murugan… - Biosensors and …, 2017 - Elsevier
Selective detection and staining of toxic amyloid plaques, a potential biomarker present in
the Alzheimer's disease (AD) brain is crucial for both clinical diagnosis and monitoring AD …