Dendrimers in RNAi Delivery Page 1 8 Dendrimers in RNAi Delivery Jose Luis Jiménez
Fuentes1, Paula Ortega2, Sara Ferrando-Martınez1, Rafael Gómez2, Manuel Leal3, Javier de …

Over the last decades, gene therapy has emerged as a pioneering therapeutic approach to
treat or prevent several diseases. Among the explored strategies, the short-term silencing of …

siRNA technology presents a helpful means of gene silencing in mammalian cells.
Advancement in the field includes enhanced attentiveness in the characterization of target …

There is a tremendous interest in moving siRNA therapeutics into a clinical setting for the
treatment of various diseases. This in itself however depends largely on the availability of …

Despite the enormous possibilities of RNAi, there still exist many problems that need to be
addressed. Obstacles in delivery, target cell transfection, stability/degradation, transient …

RNA interference (RNAi) was first literaturally reported in 1998 and has become rapidly a
promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small …

Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of
polymers has gained considerable attention for numerous biomedical applications, due …

The lack of an appropriate intracellular delivery system for therapeutic nucleic acids (TNAs)
is a major problem in molecular biology, biotechnology, and medicine. A relatively new class …

Transfection, a term derived from the phrase “infection by transformation,” is the process by
which foreign nucleic acids are introduced into cells. By this process, the phenotype of cells …

Background: Therapeutic efficacy of dreadful diseases like cancer, HIV (Human
Immunodeficiency Virus) can be enhanced by delivering molecules which regulate function …