Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model
T Kudo, H Takuwa, M Takahashi, T Urushihata… - Iscience, 2023 - cell.com
In Alzheimer's disease (AD), network hyperexcitability is frequently observed and associated
with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought …
with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought …
Phenotypic alterations in hippocampal NPY-and PV-expressing interneurons in a presymptomatic transgenic mouse model of Alzheimer's disease
I Mahar, MS Albuquerque… - Frontiers in Aging …, 2017 - frontiersin.org
Interneurons, key regulators of hippocampal neuronal network excitability and
synchronization, are lost in advanced stages of Alzheimer's disease (AD). Given that …
synchronization, are lost in advanced stages of Alzheimer's disease (AD). Given that …
[HTML][HTML] Dysfunction of somatostatin-positive interneurons associated with memory deficits in an Alzheimer's disease model
LC Schmid, M Mittag, S Poll, J Steffen, J Wagner… - Neuron, 2016 - cell.com
Alzheimer's disease (AD) is characterized by cognitive decline and neuronal network
dysfunction, but the underlying mechanisms remain unknown. In the hippocampus …
dysfunction, but the underlying mechanisms remain unknown. In the hippocampus …
Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease
In Alzheimer's disease (AD), where amyloid-β (Aβ) and tau deposits in the brain,
hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause …
hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause …
Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer's disease
Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive
decline. These impairments correlate with early alterations in neuronal network activity in AD …
decline. These impairments correlate with early alterations in neuronal network activity in AD …
Novel quantitative analyses of spontaneous synaptic events in cortical pyramidal cells reveal subtle parvalbumin-expressing interneuron dysfunction in a knock-in …
Alzheimer's disease (AD) is a neurodegenerative disorder that has become a compelling
global public health concern. Besides pathological hallmarks such as extracellular amyloid …
global public health concern. Besides pathological hallmarks such as extracellular amyloid …
Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer's disease
S Hijazi, TS Heistek, P Scheltens, U Neumann… - Molecular …, 2020 - nature.com
Neuronal network dysfunction is increasingly recognized as an early symptom in
Alzheimer's disease (AD) and may provide new entry points for diagnosis and intervention …
Alzheimer's disease (AD) and may provide new entry points for diagnosis and intervention …
Calcineurin/NFAT signaling in activated astrocytes drives network hyperexcitability in Aβ-bearing mice
P Sompol, JL Furman, MM Pleiss… - Journal of …, 2017 - Soc Neuroscience
Hyperexcitable neuronal networks are mechanistically linked to the pathologic and clinical
features of Alzheimer's disease (AD). Astrocytes are a primary defense against …
features of Alzheimer's disease (AD). Astrocytes are a primary defense against …
Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer's
In Alzheimer's disease (AD), a multitude of genetic risk factors and early biomarkers are
known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD …
known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD …
Neuronal network excitability in Alzheimer's disease: the puzzle of similar versus divergent roles of amyloid β and tau
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder that commonly
causes dementia in the elderly. Recent evidence indicates that network abnormalities …
causes dementia in the elderly. Recent evidence indicates that network abnormalities …