Mutations in the heterochronic gene lin-28 of C. elegans cause precocious development
where diverse events specific to the second larval stage are skipped. lin-28 encodes a …

Null mutations in the C. elegans heterochronic gene lin-41 cause precocious expression of
adult fates at larval stages. Increased lin-41 activity causes the opposite phenotype …

The heterochronic gene lin-28 is a regulator of developmental timing in the nematode
Caenorhabditis elegans. It must be expressed in the first larval stage and downregulated by …

ABSTRACT A hierarchy of heterochronic genes, lin-4, lin-14, lin-28 and lin-29, temporally
restricts terminal differentiation of Caenorhabditis elegans hypodermal seam cells to the …

Summary h-4 is essential for the normal temporal control of diverse postembryonic
developmental events in C. elegans./in-4 acts by negatively regulating the level of LIN-14 …

The heterochronic gene lin-28 of the nematode Caenorhabditis elegans controls the relative
timing of diverse developmental events during the animal's larval stages. lin-28 is stage …

Heterochronic genes form a regulatory pathway that controls the temporal sequence of the
Caenorhabditis elegans postembryonic cell lineage. One of these genes, lin-14, encodes a …

The heterchronic gene lin-14 controls the temporal sequence of developmental events in the
Caenorhabditis elegans postembryonic cell lineage. It encodes a nuclear protein that …

During C. elegans development, the temporal pattern of many cell lineages is specified by
graded activity of the heterochronic gene Lin-14. Here we demonstrate that a temporal …

Thelin-4gene encodes a small RNA that is required to translationally represslin-14toward
the end of the first larval stage ofCaenorhabditis elegansdevelopment. To determine if the …