A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation
Background DNA methylation (5mC) plays important roles in epigenetic regulation of
genome function. Recently, TET hydroxylases have been found to oxidise 5mC to …
genome function. Recently, TET hydroxylases have been found to oxidise 5mC to …
Uncovering the role of 5-hydroxymethylcytosine in the epigenome
Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-
known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting …
known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting …
[HTML][HTML] 5-Hydroxymethylcytosine: a stable or transient DNA modification?
MA Hahn, PE Szabó, GP Pfeifer - Genomics, 2014 - Elsevier
Abstract The DNA base 5-hydroxymethylcytosine (5hmC) is produced by enzymatic
oxidation of 5-methylcytosine (5mC) by 5mC oxidases (the Tet proteins). Since 5hmC is …
oxidation of 5-methylcytosine (5mC) by 5mC oxidases (the Tet proteins). Since 5hmC is …
In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine
Background Genome-wide methylation of cytosine can be modulated in the presence of TET
and thymine DNA glycosylase (TDG) enzymes. TET is able to oxidise 5-methylcytosine …
and thymine DNA glycosylase (TDG) enzymes. TET is able to oxidise 5-methylcytosine …
Charting oxidized methylcytosines at base resolution
DNA cytosine methylation is a key epigenetic mark that is required for normal mammalian
development. Iterative oxidation of 5-methylcytosine (5mC) by the TET family of DNA …
development. Iterative oxidation of 5-methylcytosine (5mC) by the TET family of DNA …
The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine
hydroxymethylcytosine (5hmC) is a recently discovered base in the mammalian genome,
produced upon oxidation of 5-methylcytosine (5mC) in a process catalyzed by TET proteins …
produced upon oxidation of 5-methylcytosine (5mC) in a process catalyzed by TET proteins …
Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine
SG Jin, S Kadam, GP Pfeifer - Nucleic acids research, 2010 - academic.oup.com
ABSTRACT DNA cytosine-5 methylation is a well-studied epigenetic pathway implicated in
gene expression control and disease pathogenesis. Different technologies have been …
gene expression control and disease pathogenesis. Different technologies have been …
Potential functional roles of DNA demethylation intermediates
DNA methylation in the form of 5-methylcytosine (5mC) is a key epigenetic regulator in
mammals, and the dynamic balance between methylation and demethylation impacts …
mammals, and the dynamic balance between methylation and demethylation impacts …
Nucleic acid modifications with epigenetic significance
Epigenetic modifications influence gene expression without alterations to the underlying
nucleic acid sequence. In addition to the well-known 5-methylcytosine (5mC), 5 …
nucleic acid sequence. In addition to the well-known 5-methylcytosine (5mC), 5 …
Advances in genome-wide DNA methylation analysis
R Gupta, A Nagarajan, N Wajapeyee - Biotechniques, 2010 - Taylor & Francis
The covalent DNA modification of cytosine at position 5 (5-methylcytosine; 5mC) has
emerged as an important epigenetic mark most commonly present in the context of CpG …
emerged as an important epigenetic mark most commonly present in the context of CpG …