Abstract Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of
hematologic malignancies, particularly pediatric leukemias with poor patient outcomes …

Structural chromosomal rearrangements of the Nucleoporin 98 gene (NUP98), primarily
balanced translocations and inversions, are associated with a wide array of hematopoietic …

NUP98 is fused to a variety of partner genes, including abdominal B-like HOX, in human
myeloid and T-cell malignancies via chromosomal translocation involving 11p15. NUP98 …

Chromosomal aberrations occur with great frequency and some specificity in leukemia and
other hematologic malignancies. The most common outcome of these rearrangements is the …

Fusion proteins involving Nucleoporin 98 (NUP98) are recurrently found in acute myeloid
leukemia (AML) and are associated with poor prognosis. Lack of mechanistic insight into …

Summary The nucleoporin 98 gene (NUP98) is fused to a variety of partner genes in
multiple hematopoietic malignancies. Here, we demonstrate that NUP98 fusion proteins …

Nucleoporin 98 (NUP98) is a component of the nuclear pore complex that facilitates mRNA
export from the nucleus. It is mapped to 11p15. 5 and is fused to a number of distinct …

NUP98 fusion oncoproteins (FO) are drivers in pediatric leukemias and many transform
hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered region from NUP98 …

NUP98 fusion proteins cause leukemia via unknown molecular mechanisms. All NUP98
fusion proteins share an intrinsically disordered region (IDR) in the NUP98 N terminus …

The nuclear pore complex is a transport channel embedded in the nuclear envelope and
made up of 30 different components termed nucleoporins (Nups). In addition to their …