Bioprinted biomimetic hydrogel matrices guiding stem cell aggregates for enhanced chondrogenesis and cartilage regeneration

Y Liu, L Du, H Zhang, G Li, Y Luo, Z Hu, R Xu… - Journal of Materials …, 2024 - pubs.rsc.org
Articular cartilage tissue has limited self-repair capabilities, with damage frequently
progressing to irreversible degeneration. Engineered tissues constructed through …

The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells

R Levato, WR Webb, IA Otto, A Mensinga, Y Zhang… - Acta biomaterialia, 2017 - Elsevier
Cell-laden hydrogels are the primary building blocks for bioprinting, and, also termed
bioinks, are the foundations for creating structures that can potentially recapitulate the …

Cell-laden hydrogels for osteochondral and cartilage tissue engineering

J Yang, YS Zhang, K Yue, A Khademhosseini - Acta biomaterialia, 2017 - Elsevier
Despite tremendous advances in the field of regenerative medicine, it still remains
challenging to repair the osteochondral interface and full-thickness articular cartilage …

3D tissue engineered supramolecular hydrogels for controlled chondrogenesis of human mesenchymal stem cells

H Jung, JS Park, J Yeom, N Selvapalam… - …, 2014 - ACS Publications
Despite a wide investigation of hydrogels as an artificial extracellular matrix, there are few
scaffold systems for the facile spatiotemporal control of mesenchymal stem cells (MSCs) …

Injectable stem cell-laden supramolecular hydrogels enhance in situ osteochondral regeneration via the sustained co-delivery of hydrophilic and hydrophobic …

J Xu, Q Feng, S Lin, W Yuan, R Li, J Li, K Wei, X Chen… - Biomaterials, 2019 - Elsevier
Hydrogels have been widely used as the carrier material of therapeutic cell and drugs for
articular cartilage repair. We previously demonstrated a unique host-guest macromer (HGM) …

Molecular recognition-directed site-specific release of stem cell differentiation inducers for enhanced joint repair

X Liu, Y Chen, AS Mao, C Xuan, Z Wang, H Gao, G An… - Biomaterials, 2020 - Elsevier
The remarkable difference in cell type and matrix composition between two connected parts
of a joint (cartilage and subchondral bone) makes it challenging to simultaneously …

[HTML][HTML] Fabrication of 3D-printed interpenetrating hydrogel scaffolds for promoting chondrogenic differentiation

J Guan, F Yuan, Z Mao, H Zhu, L Lin, HH Chen, J Yu - Polymers, 2021 - mdpi.com
The limited self-healing ability of cartilage necessitates the application of alternative tissue
engineering strategies for repairing the damaged tissue and restoring its normal function …

[HTML][HTML] Engineering the dynamics of biophysical cues in supramolecular hydrogels to facile control stem cell chondrogenesis for cartilage regeneration

R Yang, W Xue, X Ma, Y Ren, L Xu, W Kong… - Composites Part B …, 2023 - Elsevier
Hydrogel systems have been widely used to engineer biomimetic niches that capture
microenvironments cues to steer cell fate; however, challenges remain in inducing …

Hydrogel to guide chondrogenesis versus osteogenesis of mesenchymal stem cells for fabrication of cartilaginous tissues

J Chen, A Chin, AJ Almarza, JM Taboas - Biomedical Materials, 2020 - iopscience.iop.org
The ideal combination of hydrogel components for regeneration of cartilage and
cartilaginous interfaces is a significant challenge because control over differentiation into …

A MMP7‐sensitive photoclickable biomimetic hydrogel for MSC encapsulation towards engineering human cartilage

EA Aisenbrey, SJ Bryant - Journal of Biomedical Materials …, 2018 - Wiley Online Library
Cartilage tissue engineering strategies that use in situ forming degradable hydrogels for
mesenchymal stem cell (MSC) delivery are promising for treating chondral defects …